The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential

Mahdi, Jassem G.; Mahdi, Ali Jassem; Bowen, I. D.

doi:10.1111/j.1365-2184.2006.00377.x

Cited by 161 publications

(115 citation statements)

References 71 publications

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“…Pharmacodynamically,~-D-salicin [1] and 2-ASA [3] metabolise into 2-HBA in the small intestine and bloodstream. The metabolism of compounds [1] and [3] produces D-glucose and acetic acid respectively. Consequently, the hydrolysis of the 2-ASA [3] does not agree with the mechanism for the inhibition of COX-2 (4).…”

Section: Fig 1 the Chemical Structures Of Fj-d-salicin (Possess Benmentioning

confidence: 99%

Pharmacological Importance of Simple Phenolic Compounds on Inflammation, Cell Proliferation and Apoptosis with a Special Reference to β-D-Salicin and Hydroxybenzoic Acid

et al. 2013

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Simple phenolic (SP) compounds are natural products that exhibit multiple pharmacological functions. The best known of these compounds is β-D-salicin, the first discovered phenolic glycoside and salicylic acid, or 2-hydroxybenzoic acid (2-HBA). Both of these compounds have attracted the interest of scientists in various interdisciplinary fields, including chemistry, pharmacology and medicine. Although β-D-salicin is found in various plants, it is often associated with willow, as it was first discovered in this species of plant. While the presence of glucose in β-D-salicin improves the physicochemical properties of the benzyl moiety, β-D-salicin itself does not have anti-inflammatory or anti-proliferative activity until it is metabolised into 2-HBA in the gastrointestinal tract and blood stream. Likewise, the majority of 2-acetoxybenzoic acid (2-ABA), or acetoxysalicylic acid also undergoes metabolic hydrolysis into 2-HBA. 2-HBA has been shown to play a role in modulating both inflammation and cancer partly through the inhibition of cyclooxygenase-2 (COX-2). It is now clear that 2-HBA most likely acts on the transcription factor NF-κB, which regulates the transcription of COX-2 thereby suppressing inflammation and cell proliferation and promoting apoptosis. Other phenolates, also exhibit anti-inflammation and anti-proliferation activities like the 4-hydroxybenzoate zinc (4-HBZn) complex, which was previously shown to preferentially inhibit COX-2 compared to 2-HBA and ASA. This review aims to collect all the available information related to β-D-salicin and other SP compounds in order to promote a new perspective of this interesting class of compounds and encourage further research into their pharmacological and clinical properties.

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Section: Fig 1 the Chemical Structures Of Fj-d-salicin (Possess Benmentioning

confidence: 99%

Pharmacological Importance of Simple Phenolic Compounds on Inflammation, Cell Proliferation and Apoptosis with a Special Reference to β-D-Salicin and Hydroxybenzoic Acid

et al. 2013

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“…Since acetylsalicylic acid, a synthetic derivative of salicin produced from willow bark, was first introduced in 1897 1 , natural products have become major sources for chemical compounds used as starting materials 2 . In fact, approximately 40% of current mono-molecular medicinal drugs are derived directly or indirectly from plant species and their preparations 3 .…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and antidiabetic activities of Rehmannia glutinosa tuberous root extracts

Jeong¹,

Kim²,

Hyun³

et al. 2013

ScienceAsia

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To analyse the antioxidant and antidiabetic activities of Rehmannia glutinosa tuberous roots, extracts with nine different solvents were investigated.Antioxidant activity was measured with two methods, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and reducing power. Each extract exhibited a dose-dependent free radical scavenging action against DPPH and a reducing power, but diverse antioxidant activities. To determine the antidiabetic activity, we measured the α-glucosidase inhibitory capacity of each extract. We found that 10 µg/ml of 60% MeOH or 80% of MeOH extract inhibited more than 90% of α-glucosidase activity, and this inhibitory activity was not mediated by catalpol, a major iridoid constituent of R. glutinosa tuberous roots. Overall, the data suggested that the tuberous roots of R. glutinosa have potential as natural antioxidants and antidiabetics.

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“…The willow tree is the most abundant among the Salix spp. and has been used to relieve pain and inflammation for thousands of years [1]. Salix pseudo-lasiogyne H.…”

mentioning

confidence: 99%

Neuroprotective Compounds from Salix pseudo-lasiogyne Twigs and Their Anti-Amnesic Effects on Scopolamine-Induced Memory Deficit in Mice

et al. 2012

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The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential

Cited by 161 publications

References 71 publications

Pharmacological Importance of Simple Phenolic Compounds on Inflammation, Cell Proliferation and Apoptosis with a Special Reference to β-D-Salicin and Hydroxybenzoic Acid

Pharmacological Importance of Simple Phenolic Compounds on Inflammation, Cell Proliferation and Apoptosis with a Special Reference to β-D-Salicin and Hydroxybenzoic Acid

In vitro antioxidant and antidiabetic activities of Rehmannia glutinosa tuberous root extracts

Neuroprotective Compounds from Salix pseudo-lasiogyne Twigs and Their Anti-Amnesic Effects on Scopolamine-Induced Memory Deficit in Mice

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