The Histopathology of Filamentary Keratitis

Filamentary Keratopathy as a Chronic Problem in the Long-Term Care of Patients in a Vegetative State

“…4,12 One case study that we found describes the treatment of FK with a soft contact bandage lens in a patient who was comatose for 10 months. 6 However, in that case, the vegetative state was not described and there was no long-term follow-up. After an initial positive effect, the lenses frequently came out, and the patient died 4 months later.…”

“…10 Brainstem injuries can be associated with FK, but only 2 previous case reports are available about coma in the first years. 6,11 It is difficult to compare these reports with our cases of a long-term vegetative state because the vegetative state was not defined and the cause was not described in them. Moreover, in contrast to coma, in patients in a vegetative state, the function of the brainstem is completely or partially preserved; the main problem is absence of function in the cerebral cortex.…”

Filamentary Keratopathy as a Chronic Problem in the Long-Term Care of Patients in a Vegetative State

“…4,12 One case study that we found describes the treatment of FK with a soft contact bandage lens in a patient who was comatose for 10 months. 6 However, in that case, the vegetative state was not described and there was no long-term follow-up. After an initial positive effect, the lenses frequently came out, and the patient died 4 months later.…”

“…10 Brainstem injuries can be associated with FK, but only 2 previous case reports are available about coma in the first years. 6,11 It is difficult to compare these reports with our cases of a long-term vegetative state because the vegetative state was not defined and the cause was not described in them. Moreover, in contrast to coma, in patients in a vegetative state, the function of the brainstem is completely or partially preserved; the main problem is absence of function in the cerebral cortex.…”

Ocular Surface Complications after Trabeculectomy: Incidence, Risk Factors, Time Course and Prognosis

“…Corneal epithelial defects are characterized by a partial or complete absence of corneal epithelium; they are a common complication of surgical trauma [3]. Filamentary keratitis is characterized by the presence of fine strands of degenerated epithelial cells and mucous attached to the cornea [4,5]. Dellen are small, saucer-like excavations at the margin of the cornea.…”

“…The later onset of filamentary keratitis can probably be accounted for by the complicated mechanism of step-by-step formation of the filaments. The corneal epithelial toxicity of antifibrotic agents or instability of the tear film caused by the presence of the bleb formation damages the basal corneal epithelium, or Bowman's layer [5]. With time, these affected areas of epithelium can become elevated.…”

Investigation of the Corneal Filament in Filamentary Keratitis

“…In summary, although our new theory about the mechanism behind filament generation diverges from that previously reported, 11,13,14 our immunohistologic study of a large number of filament samples obtained from the cornea have led us to the FIGURE 7. Schema for proposed mechanism of filament generation.…”

Filamentary Keratopathy as a Chronic Problem in the Long-Term Care of Patients in a Vegetative State

“…4,12 One case study that we found describes the treatment of FK with a soft contact bandage lens in a patient who was comatose for 10 months. 6 However, in that case, the vegetative state was not described and there was no long-term follow-up. After an initial positive effect, the lenses frequently came out, and the patient died 4 months later.…”

“…10 Brainstem injuries can be associated with FK, but only 2 previous case reports are available about coma in the first years. 6,11 It is difficult to compare these reports with our cases of a long-term vegetative state because the vegetative state was not defined and the cause was not described in them. Moreover, in contrast to coma, in patients in a vegetative state, the function of the brainstem is completely or partially preserved; the main problem is absence of function in the cerebral cortex.…”

Ocular Surface Complications after Trabeculectomy: Incidence, Risk Factors, Time Course and Prognosis

“…Corneal epithelial defects are characterized by a partial or complete absence of corneal epithelium; they are a common complication of surgical trauma [3]. Filamentary keratitis is characterized by the presence of fine strands of degenerated epithelial cells and mucous attached to the cornea [4,5]. Dellen are small, saucer-like excavations at the margin of the cornea.…”

“…The later onset of filamentary keratitis can probably be accounted for by the complicated mechanism of step-by-step formation of the filaments. The corneal epithelial toxicity of antifibrotic agents or instability of the tear film caused by the presence of the bleb formation damages the basal corneal epithelium, or Bowman's layer [5]. With time, these affected areas of epithelium can become elevated.…”

Investigation of the Corneal Filament in Filamentary Keratitis

“…In summary, although our new theory about the mechanism behind filament generation diverges from that previously reported, 11,13,14 our immunohistologic study of a large number of filament samples obtained from the cornea have led us to the FIGURE 7. Schema for proposed mechanism of filament generation.…”

Filamentary Keratopathy as a Chronic Problem in the Long-Term Care of Patients in a Vegetative State

“…4,12 One case study that we found describes the treatment of FK with a soft contact bandage lens in a patient who was comatose for 10 months. 6 However, in that case, the vegetative state was not described and there was no long-term follow-up. After an initial positive effect, the lenses frequently came out, and the patient died 4 months later.…”

“…10 Brainstem injuries can be associated with FK, but only 2 previous case reports are available about coma in the first years. 6,11 It is difficult to compare these reports with our cases of a long-term vegetative state because the vegetative state was not defined and the cause was not described in them. Moreover, in contrast to coma, in patients in a vegetative state, the function of the brainstem is completely or partially preserved; the main problem is absence of function in the cerebral cortex.…”

Ocular Surface Complications after Trabeculectomy: Incidence, Risk Factors, Time Course and Prognosis

“…Corneal epithelial defects are characterized by a partial or complete absence of corneal epithelium; they are a common complication of surgical trauma [3]. Filamentary keratitis is characterized by the presence of fine strands of degenerated epithelial cells and mucous attached to the cornea [4,5]. Dellen are small, saucer-like excavations at the margin of the cornea.…”

“…The later onset of filamentary keratitis can probably be accounted for by the complicated mechanism of step-by-step formation of the filaments. The corneal epithelial toxicity of antifibrotic agents or instability of the tear film caused by the presence of the bleb formation damages the basal corneal epithelium, or Bowman's layer [5]. With time, these affected areas of epithelium can become elevated.…”

Investigation of the Corneal Filament in Filamentary Keratitis

“…In summary, although our new theory about the mechanism behind filament generation diverges from that previously reported, 11,13,14 our immunohistologic study of a large number of filament samples obtained from the cornea have led us to the FIGURE 7. Schema for proposed mechanism of filament generation.…”