2019
DOI: 10.1002/ijc.32116
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Abstract: The lysine‐specific demethylase 6A/UTX (gene name KDM6A) acts as a component of the COMPASS complex to control gene activation. UTX demethylates H3K27me2/3 at genes and enhancers. Deleterious mutations in KDM6A are found in many cancer types, prominently urothelial carcinoma and certain T‐cell leukemias. In certain cancers, however, UTX supports oncogenic transcription factors, e.g. steroid hormone receptors in breast and prostate cancer. In fetal development, UTX regulates lineage choice and cell differentiat… Show more

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Cited by 66 publications
(51 citation statements)
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References 65 publications
(153 reference statements)
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“…Mutations inactivating UTX are found across all stages of urothelial carcinoma (UC), albeit more commonly in lower stage tumors [11], and intriguingly, across all molecular subtypes of muscle-invasive bladder cancers (MIBC) [2]. In particular, according to the large TCGA study [10], there is no significant difference in their frequency between cancers with a basal-squamous (BASQ) phenotype, which present with markers of basal urothelial cells, and cancers with luminal phenotypes exhibiting markers of intermediate and luminal differentiated urothelial cells.…”
Section: Discussionmentioning
confidence: 99%
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“…Mutations inactivating UTX are found across all stages of urothelial carcinoma (UC), albeit more commonly in lower stage tumors [11], and intriguingly, across all molecular subtypes of muscle-invasive bladder cancers (MIBC) [2]. In particular, according to the large TCGA study [10], there is no significant difference in their frequency between cancers with a basal-squamous (BASQ) phenotype, which present with markers of basal urothelial cells, and cancers with luminal phenotypes exhibiting markers of intermediate and luminal differentiated urothelial cells.…”
Section: Discussionmentioning
confidence: 99%
“…The function of UTX during urothelial regeneration, which involves repletion of intermediate luminal, and especially umbrella cells, from the lower epithelial layers, should therefore be studied. Since interactions of UTX with a broad range of lineage-specific transcription factors have been described (reviewed in [2]), another not necessarily exclusive explanation is that UTX may be required as a co-activator for specific transcription factors establishing the epigenetic state of KRT14 low /KRT5+ cells. These issues will require further experimental investigation.…”
Section: Discussionmentioning
confidence: 99%
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“…37,38 In the present study, we demonstrate the function of the UTX/miR-24 epigenetic network in the vascular regeneration of SCI for the very first time ( Figure 8D). UTX has been functionally linked to many physical and pathological processes, including embryonic development, 39,40 tumor progression, [41][42][43][44] inflammation, 45 and stem cell differentiation 46,47 by H3K27 demethylation-dependent or -independent gene transcription. Although UTX was shown to be required for nuclear factor kB (NF-kB)-dependent inflammatory response of ECs, 48 the regenerative regulation mediated by UTX in SCI is still unclear.…”
Section: Discussionmentioning
confidence: 99%