The Histogenesis of Nevoid Tumors of the Skin

Kligman, Albert M.; Pinkus, Hermann

doi:10.1001/archderm.1960.03730060038007

Cited by 68 publications

(4 citation statements)

References 4 publications

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“…26 Benign adnexal tumors/hamartomas such as trichoepithelioma, folliculo-sebaceous cystic hamartoma, cylindroma, and trichodiscoma are bi-phasic lesions (epithelial and mesenchymal) that are postulated to have a stromal response which attempts to re-create the normal relationship between the adnexae (follicular, folliculo-sebaceous, or eccrine unit) and their surrounding mesenchyme. 27 In this article, we report the CD34-reactive trichodiscoma immunohistochemical profile of one case of trichodiscoma. Shea et al 9 had previously anticipated that, given the abundance of CD34 þ cells in the perifollicular stroma, trichodiscoma should be reactive for CD34.…”

Section: Discussionmentioning

confidence: 94%

CD34‐reactive trichodiscoma

Chartier

Reed²,

Mandavilli

et al. 2004

J Cutan Pathol

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Section: Discussionmentioning

confidence: 94%

CD34‐reactive trichodiscoma

Chartier

Reed²,

Mandavilli

et al. 2004

J Cutan Pathol

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“…Trichofolliculoma is a hamartomatous tumor originating from the hair follicle [3]. Meischer first described this entity in 1944 and named it trichofolliculoma [4].…”

Section: Discussionmentioning

confidence: 99%

“…In 1957, Hyman and Clayman [5] reported a similar case and named it "hair follicle nevus." Kligman and Pinkus [3], on the other hand, stated that the definition of nevus would not be an appropriate definition since this tumor shows different stages of hair follicle differentiation histopathologically, and the name "tricofolliculoma," previously made by Meischer, was accepted for this tumor. Compared to other adnexal tumors, it is observed less frequently and mostly has a characteristic appearance that facilitates diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A Rare Cutaneous Hamartomatous Adnexal Tumor: Trichofolliculoma

Zekey

Kurtipek

2022

Skin Appendage Disord

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Introduction: Trichofolliculoma is a very rare, benign hamartomatous skin adnexal tumor originating from the hair follicle. The tumor which presents as a papule or nodule is usually observed on the scalp and face. Case Presentation: We report the case of a 49-year-old female who presented with a solitary papule on the nose. The lesion which was observed macroscopically and dermoscopically compatible with trichofolliculoma was completely removed by punch biopsy. The diagnosis of trichofolliculoma was confirmed histopathologically, and no recurrence was observed in the follow-up. Conclusion: Trichofolliculomas can macroscopically mimic some skin cancers such as basal cell carcinoma and sebaceous carcinoma. Awareness of its typical clinical and dermoscopic features facilitates diagnosis and prevents aggressive surgical intervention.

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“…[3] In addition, there is a hypothesis that all epidermal and adnexal epithelia are multipotent and that BCCs arise from these epithelia; however, this is not completely elucidated. [4] Since BCC arising in the umbilicus without a hair follicle is relatively rare, we report 2 cases of umbilical BCC associated with intra- and peritumoral sweat gland structures.…”

Section: Introductionmentioning

confidence: 99%

Basal cell carcinoma of the umbilicus associated with sweat gland structures: Two case reports

et al. 2023

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Rationale: Basal cell carcinoma (BCC) arising in the umbilicus is relatively rare, and in particular, there have been few reports mentioning peritumoral sweat gland structures histopathologically. We herein, report 2 cases of umbilical BCC with sweat gland structures within and around the tumor.Patient concerns: A 61-year-old woman had a 2-year history of black exudative plaque in her umbilicus, and an 80-year-old woman had a 6-month history of dark brownish plaque in the umbilicus, with exudation 2 months prior to her first visit.Diagnoses: Based on the histopathological finding, both cases were confirmed as BCC. The results of immunohistochemical staining showed that the tumor cells were Ber-EP4 positive. In addition, EMA-positive glandular structures were seen within and around the tumor.Interventions: Curative resection at the level of the linea alba on the bottom side was performed.Outcomes: No relapse has been observed since resection in either patient.Lessons: We herein report 2 cases of umbilical BCC with sweat glands and ducts. Although whether peri-and/or intra-tumor sweat gland structures are the source of the tumor or arise by transdifferentiation from tumor cells remains unclear, these findings may provide clues to help understand the morphopathogenesis of umbilical BCC in the future.Abbreviations: BCC = basal cell carcinoma, FEP = fibroepithelioma of Pinkus.

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The Histogenesis of Nevoid Tumors of the Skin

Cited by 68 publications

References 4 publications

CD34‐reactive trichodiscoma

CD34‐reactive trichodiscoma

A Rare Cutaneous Hamartomatous Adnexal Tumor: Trichofolliculoma

Basal cell carcinoma of the umbilicus associated with sweat gland structures: Two case reports

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