The hippocampus: Functional and structural correlations

Baxendale, Sallie

doi:10.1016/s1059-1311(95)80089-1

Cited by 46 publications

(25 citation statements)

References 47 publications

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“…Nevertheless, other authors found correlation only between visual memory deficit and right TLE 11,12 . This is not in keeping with studies that showed a higher sensitivity of verbal memory tests in the assessment of left TLE in adults 3,6,13 . Finally, other authors found no correlation between laterality of the lesion and memory deficits in children with TLE [14][15] .…”

contrasting

confidence: 79%

Memory in children with symptomatic temporal lobe epilepsy

Guimarães

Rzezak

Fuentes

et al. 2014

Arq. Neuro-Psiquiatr.

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In children with temporal lobe epilepsy (TLE), memory deficit is not so well understood as it is in adults. The aim of this study was to identify and describe memory deficits in children with symptomatic TLE, and to verify the influence of epilepsy variables on memory. We evaluated 25 children with TLE diagnosed on clinical, EEG and MRI findings. Twenty-five normal children were compared with the patients. All children underwent a neuropsychological assessment to estimate intellectual level, attention, visual perception, handedness, and memory processes (verbal and visual: short-term memory, learning, and delayed recall). The results allowed us to conclude: besides memory deficits, other neuropsychological disturbances may be found in children with TLE such as attention, even in the absence of overall cognitive deficit; the earlier onset of epilepsy, the worse verbal stimuli storage; mesial lesions correlate with impairment in memory storage stage while neocortical temporal lesions correlate with retrieval deficits.Keywords: neuropsychology, epilepsy, children, childhood, temporal lobe epilepsy, memory. RESUMOEm crianças com epilepsia de lobo temporal (ELT) os problemas de memória não são tão bem compreendidos como em adultos. O objetivo desse estudo foi identificar e descrever déficits de memória em crianças com ELT sintomática e verificar a influência de variáveis da epilepsia na memória. Avaliamos 25 crianças com ELT com diagnóstico baseado em aspectos clínicos, eletrencefalográficos e de neuroimagem. Vinte e cinco crianças normais foram comparadas com os pacientes. Todas as crianças foram submetidas à avaliação neuropsicológica para estimar nível intelectual, atenção, percepção visual, dominância manual, e processos de memória (verbal e visual: memória a curto prazo, aprendizado e recuperação tardia). Os resultados nos permitiram concluir que: além de déficit de memória, outros distúrbios neuropsicológicos podem ser encontrados em crianças com ELT, tais como déficit de atenção, mesmo na ausência de déficit cognitivo global; quanto mais precoce o início da epilepsia, pior o armazenamento verbal; lesões mesiais se correlacionam com prejuízo no armazenamento de memória enquanto lesões temporais neocorticais se correlacionam com prejuízos de evocação.Palavras-chave: neuropsicologia, epilepsia, crianças, infância, epilepsia de lobo temporal, memória.

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contrasting

confidence: 79%

Memory in children with symptomatic temporal lobe epilepsy

Guimarães

Rzezak

Fuentes

et al. 2014

Arq. Neuro-Psiquiatr.

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“…MRI measures are exclusively concerned with hippocampal integrity, whereas the IAP measures the memory capacity of the whole hemisphere. Although the hippocampus plays a critical role in memory functioning (38), there is also evidence to suggest that extrahippocampal structures within the temporal lobes and elsewhere contribute to memory processes (39), particularly recognition memory (40,4 1). Indeed, because the hippocampus takes its blood supply from both the internal carotid and the posterior cerebral arteries, it remains unknown to what degree the hippocampus is affected in each patient tested on the IAP (42).…”

Section: Discussionmentioning

confidence: 99%

The Relation Between Quantitative MRI Measures of Hippocampal Structure and the Intracarotid Amobarbital Test

Baxendale¹,

Paesschen²,

Thompson³

et al. 1997

Epilepsia

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Summary: Purpose:The increasing sophistication of quantitative magnetic resonance imaging (MRI) techniques has generated hopes that they may eventually supersede the intracarotid amobarbital procedure (IAP) in the presurgical screening for bilateral abnormalities in prospective candidates for temporal lobe epilepsy surgery. As the first step toward this aim, the purpose of this study was to examine the relationship between these measures of structural and functional integrity.Methods: We examined the relation between memory performance and pasdfail rates on the IAP and two MRI measures of hippocampal integrity: hippocampal volumes, adjusted for intracranial volume (HC,,,) and hippocampal T, relaxometry (HCT,), in 48 patients with medically intractable temporal lobe epilepsy, who underwent the IAP as part of their presurgical evaluation for temporal lobectomy.Results: The unilateral memory scores from the IAP were not significantly correlated with the corresponding HC,,, or HCT, measures in the right-and left-temporal-lobe groups. However, the MRI measures of hippocampal asymmetry (right minus left HC,,,, right minus left HCT,) were significantly correlated with our measure of functional asymmetry, the right minus left hemisphere memory score from the IAP, supporting the role of the IAP in lateralising temporal lobe dysfunction. Forty-six patients with unilateral hippocampal sclerosis and concordant EEG studies passed the IAP. Two patients failed the memory component of the IAP. In both cases, other presurgical investigations suggested bilateral abnormalities. Conclusions:We conclude that patients with unilateral hippocampal sclerosis, established by a rigorous quantitative MRI protocol, and concordant ictal and interictal EEG findings may not be at risk for postoperative amnesia, despite baseline neuropsychological deficits suggestive of bilateral disturbance.

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“…Introduziu-se, mais recentemente, a sequência FLAIR, capaz de fornecer imagens fortemente pesadas em T2 e de eliminar o sinal do líquor, facilitando a detecção de anormalidades corticais ou periventriculares, possibilitando, assim, uma documentação mais sensível de alteração da intensidade de sinal do hipocampo, anulando os artefatos de efeito de volume parcial do líquor do corno inferior [11][12][13] . Fillipi e col. 14 comparam as sequências Fast-FLAIR, FLAIR-HASTE e FLAIR-EPI, na detecção de placas de esclerose múltipla, em 46 pacientes, evidenciando melhor qualidade de imagem nas sequências FLAIR-EPI e FLAIR-HASTE e ressaltam a importância da primeira, principalmente em pacientes não colaborativos, devido à sua rapidez.…”

Section: Flair-epi (C) Em Relação a Fse Dp (A) E Fse T2 (B) A Atrofunclassified

Uso da sequência FLAIR-EPI na análise da esclerose mesial temporal

Júnior

Goyanna

Matos

et al. 2001

Arq. Neuro-Psiquiatr.

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O objetivo deste estudo é analisar as alterações morfológicas e de intensidade de sinal das regiões hipocampais em pacientes, com epilepsia temporal fármaco-resistente. Para tal, estudamos 8 pacientes com esclerose mesial temporal, utilizando aparelhagem de RM de 1,5T, com sequências Spin Eco - SE, Fast Spin Eco - FSE, Fluid Atenuation Inversion Recovery, com Eco Planar Imaging - FLAIR-EPI. Observamos a superioridade da sequência FLAIR na detecção do aumento da intensidade de sinal da região hipocampal, particularmente com cortes coronais, em relação às sequências SE e FSE, com a vantagem de ser uma técnica de rápida execução. A sequência STIR evidenciou adelgaçamento da cortical do hipocampo, na metade dos casos que apresentavam alteração de sinal.

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The hippocampus: Functional and structural correlations

Cited by 46 publications

References 47 publications

Memory in children with symptomatic temporal lobe epilepsy

Memory in children with symptomatic temporal lobe epilepsy

The Relation Between Quantitative MRI Measures of Hippocampal Structure and the Intracarotid Amobarbital Test

Uso da sequência FLAIR-EPI na análise da esclerose mesial temporal

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