Olca Basturk, Zhaohai Yang, Laura H. Tang, Ralph H. Hruban, Volkan Adsay, Chad M. McCall, Alyssa M. Krasinskas, Kee-Taek Jang, Wendy L. Frankel, Serdar Balci, Carlie Sigel, David S. Klimstra
The 2010 WHO classification recommends that pancreatic neuroendocrine tumors should be graded based on mitotic rate and Ki67 index, with grade 2 (G2) pancreatic neuroendocrine tumor (PanNET) defined as having a mitotic rate of 2–20 mitotic figures/10 high power fields (HPF) or a Ki67 index of 3–20%. Grade 3 (G3) pancreatic neuroendocrine carcinoma (NEC) is defined as having >20 mitotic figures/10 HPF or a Ki67 index of >20%. However, some PanNETs show discordance between the mitotic rate and Ki67 …
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