2008
DOI: 10.1001/archderm.144.7.922
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The Hidden Face of Venous Malformations

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Cited by 22 publications
(12 citation statements)
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References 38 publications
(32 reference statements)
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“…3 Injected sclerosants chemically irritate vascular endothelial cells, leading to activation of the coagulation system and thrombotic obliteration of the venous anomaly and outflow vein. 5 Sodium tetradecyl sulfate is preferred as a sclerosing agent because it is less toxic and is associated with less frequent skin necrosis, neurologic complications, and systemic complications. 6 Anaphylactic reaction to sodium tetradecyl sulfate is rare but has been reported.…”
Section: Discussionmentioning
confidence: 99%
“…3 Injected sclerosants chemically irritate vascular endothelial cells, leading to activation of the coagulation system and thrombotic obliteration of the venous anomaly and outflow vein. 5 Sodium tetradecyl sulfate is preferred as a sclerosing agent because it is less toxic and is associated with less frequent skin necrosis, neurologic complications, and systemic complications. 6 Anaphylactic reaction to sodium tetradecyl sulfate is rare but has been reported.…”
Section: Discussionmentioning
confidence: 99%
“…La Ang-2 se localiza en los cuerpos endoteliales de Webel-Palade y es rápidamente liberada tras la activación endotelial. La Ang es ligando de la tirosincinasa Tie-2 que actúa como un regulador crítico en la estabilización y maduración de nuevos vasos 9 . Recientemente hemos apreciado en una serie de 31 pacientes (11 malformaciones venosas extensas y 20 síndromes de Klippel-Trenaunay) un incremento sérico de los niveles de Tie-2, metaloproteinasa-9 y Ang-2, así como de los niveles plasmáticos de dímero-D, activador tisular del plasminógeno, inhibidor del activador del plasminógeno y factor Von-Willebrand respecto a controles sanos 10 .…”
Section: Etiopatogeniaunclassified
“…Los niveles plasmá-ticos de dímero-D pueden ser útiles para monitorizar la terapia anticancerosa de la heparina en estos pacientes. Extrapolando los datos anteriores se puede hipotetizar que la heparina de bajo peso molecular, además de su acción anticoagulante puede tener un efecto antiangiogénico sobre las malformaciones venosas controlando el desarrollo y expansión de nuevos vasos 9 .…”
Section: Etiopatogeniaunclassified
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“…3 Long-term LMWH therapy has been proposed only in cases where fibrinogen levels are decreased. 15 Coagulation disturbances occur at a high frequency in patients with venous malformations, and are associated with potentially serious thrombotic and haemorrhagic complications. It is important to obtain accurate diagnoses of coagulation abnormalities associated with vascular lesions to guide appropriate treatment, as differences in laboratory parameters between coagulopathies can be subtle.…”
Section: Casementioning
confidence: 99%