The Hidden Cost of Meth: Appraising the Socioeconomic Burden of Methamphetamine-Associated Cardiomyopathy

Reddy, Pavan; Elkayam, Uri

doi:10.1161/circoutcomes.121.008214

Cited by 3 publications

(8 citation statements)

References 8 publications

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“…It has been theorized that heart failure, a clinically significant reduction in left ventricle EF associated with progressive LV dilatation and cardiac remodeling, will have a heighted risk for cardioembolic stroke [33]. Our study corroborated findings from previous reports that methamphetamine abusers have significantly lower left ventricle EF than non-abusers [17,20,28,29]. Of note, methamphetamine associated non-ischemic cardiomyopathy can be reversible and that methamphetamine cessation is associated with improvement in functional status [10,23,33].…”

Section: Discussionsupporting

confidence: 89%

“…Public education and government policies are needed to increase the awareness of the major health concerns of methamphetamine use and the socioeconomic burden of methamphetamine associated disabilities [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Our cohort study corroborates previous reports on the younger and male predominance in patients with methamphetamine-associated cardiomyopathy [10, 27-29] and stroke [11, 12] . Public education and government policies are needed to increase the awareness of the major health concerns of methamphetamine use and the socioeconomic burden of methamphetamine associated disabilities [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Compared with non-abusers, methamphetamine abusers have more severe dilated CMP on echocardiography [18]. Methamphetamine use has been increasingly identified as a major cause of cardiomyopathy and cardiac death in young adults [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Cardiomyopathy in patients with acute ischemic stroke and methamphetamine use: Relevance for cardioembolic stroke and outcome

Lee,

Liu,

Blackwill

et al. 2023

Preprint

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Methamphetamine use has emerged as a major risk factor of cardiovascular and cerebrovascular disease in young adults. The aim of this study was to investigate the relevance of methamphetamine use and cardiomyopathy in patients with acute ischemic stroke.We performed a retrospective study of consecutive patients with acute ischemic stroke admitted at our medical center between 2019 and 2022. All patients were screened for methamphetamine use and cardiomyopathy defined as left ventricular ejection fraction ≤ 45%. Methamphetamine use was identified by self-reported history of use and/or positive urine drug screen. Logistic regression model was performed to analyze the relevance of methamphetamine-associated cardiomyopathy and cardioembolic stroke.Among 973 consecutive patients screened for the study, 48 (4.9%) were identified to have methamphetamine use. Compared with Non-meth group (n=892), the patients in the Meth group were significantly younger (53.2 ± 10.0 vs. 69.7 ± 15.2, p <0.001), more likely male (76.6% vs. 50.0%, p <0.001), and associated with significantly higher rate of cardiomyopathy (30.4% vs. 14.0%, p <0.01). They were also less likely to have history of atrial fibrillation (8.7% vs. 33.4%, p<0.01) or hyperlipidemia (28.3% vs. 51.7%, p <0.01). Compared with patients with cardiomyopathy without methamphetamine use, those with methamphetamine use and cardiomyopathy had better functional outcome at 3 months, likely due to younger age and fewer comorbidities. In the logistic regression model, methamphetamine-associated cardiomyopathy was found to be a significant risk factor of cardioembolic stroke (OR 2.88, 95% CI 1.81-4.58, p < 0.0001).Our results demonstrate that methamphetamine use increases the risk of cardiomyopathy and cardioembolic stroke in young adults.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardiomyopathy in patients with acute ischemic stroke and methamphetamine use: Relevance for cardioembolic stroke and outcome

Lee,

Liu,

Blackwill

et al. 2023

Preprint

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“… 18 Methamphetamine use has been increasingly identified as a major cause of cardiomyopathy and cardiac death in young adults. 19 , 20 , 21 …”

mentioning

confidence: 99%

Cardiomyopathy in Patients With Acute Ischemic Stroke and Methamphetamine Use: Relevance for Cardioembolic Stroke and Outcome

Lee,

Liu,

Blackwill

et al. 2024

JAHA

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Background Methamphetamine use has emerged as a major risk factor for cardiovascular and cerebrovascular disease in young adults. The aim of this study was to investigate a possible association of methamphetamine use with cardioembolic stroke. Methods and Results We performed a retrospective study of patients with acute ischemic stroke admitted at our medical center between 2019 and 2022. All patients were screened for methamphetamine use and cardiomyopathy, defined as left ventricular ejection fraction ≤45%. Among 938 consecutive patients, 46 (4.9%) were identified as using methamphetamine. Compared with the nonmethamphetamine group (n=892), the methamphetamine group was significantly younger (52.8±9.6 versus 69.7±15.2 years; P <0.001), included more men (78.3% versus 52.8%; P <0.001), and had a significantly higher rate of cardiomyopathy (30.4% versus 14.0%; P <0.01). They were also less likely to have a history of atrial fibrillation (8.7% versus 33.4%; P <0.01) or hyperlipidemia (28.3% versus 51.7%; P <0.01). Compared with patients with cardiomyopathy without methamphetamine use, the patients with cardiomyopathy with methamphetamine use had significantly lower left ventricular ejection fraction (26.0±9.59% versus 32.47±9.52%; P <0.01) but better functional outcome at 3 months, likely attributable to significantly younger age and fewer comorbidities. In the logistic regression model of clinical variables, methamphetamine‐associated cardiomyopathy was found to be significantly associated with cardioembolic stroke (odds ratio, 1.79 [95% CI, 1.04–3.06]; P <0.05). Conclusions We demonstrate that methamphetamine use is significantly associated with cardiomyopathy and cardioembolic stroke in young adults.

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New insight into methamphetamine-associated heart failure revealed by transcriptomic analyses: Circadian rhythm disorder

Zhang

Chen

Zhao

et al. 2022

Toxicology and Applied Pharmacology

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The Hidden Cost of Meth: Appraising the Socioeconomic Burden of Methamphetamine-Associated Cardiomyopathy

Cited by 3 publications

References 8 publications

Cardiomyopathy in patients with acute ischemic stroke and methamphetamine use: Relevance for cardioembolic stroke and outcome

Cardiomyopathy in patients with acute ischemic stroke and methamphetamine use: Relevance for cardioembolic stroke and outcome

Cardiomyopathy in Patients With Acute Ischemic Stroke and Methamphetamine Use: Relevance for Cardioembolic Stroke and Outcome

New insight into methamphetamine-associated heart failure revealed by transcriptomic analyses: Circadian rhythm disorder

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