1995
DOI: 10.1590/s0037-86821995000300002
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The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs

Abstract: Jo ã o J o s é P ereira daThis serial study aimed to establish a dynamic physiopathological profile of the hemorrhagic phenomena that occur in leptospirosis. The construction of such a profile was made feasible by the adoption of an experimental model that could adequately reproduce the morbidity found in humans.Our experimental approach was justified by the present lack of conclusive information in the literature, most of which is taken up with results obtained from biopsies and necropsies. Such find ings do … Show more

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Cited by 21 publications
(17 citation statements)
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“…Higgins and Couisineau, 21,38,39 working with serovar Icterohaemorrhagiae, described thrombocytopenia, "deposits resembling fibrin" in medium-sized arteries in the lung, and an elevation of fibrinogen degradation products in the setting of elevated fibrinogen levels, and concluded that DIC explained these findings. Pereira da Silva 23 and colleagues, working with serovar Copenhageni, also described thrombocytopenia, normal fibrinogen levels, and "slight deposits of fibrin" in capillaries of liver, kidney, and muscle, and concluded that DIC was responsible for the hemorrhagic phenomena observed, although fibrinogen degradation products were not measured. DIC is not believed to be a factor in human leptospirosis.…”
Section: Discussionmentioning
confidence: 99%
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“…Higgins and Couisineau, 21,38,39 working with serovar Icterohaemorrhagiae, described thrombocytopenia, "deposits resembling fibrin" in medium-sized arteries in the lung, and an elevation of fibrinogen degradation products in the setting of elevated fibrinogen levels, and concluded that DIC explained these findings. Pereira da Silva 23 and colleagues, working with serovar Copenhageni, also described thrombocytopenia, normal fibrinogen levels, and "slight deposits of fibrin" in capillaries of liver, kidney, and muscle, and concluded that DIC was responsible for the hemorrhagic phenomena observed, although fibrinogen degradation products were not measured. DIC is not believed to be a factor in human leptospirosis.…”
Section: Discussionmentioning
confidence: 99%
“…1,9 There have been two reports that disseminated intravascular coagulation (DIC) was associated with the hemorrhage caused by serogroup Icterohemorrhagiae in guinea pigs. 21,23 These reports, however, did not demonstrate significant small vessel fibrin deposition, fibrinogen consumption, or convincing release of fibrin degradation products. DIC is not mentioned as a feature of human leptospirosis.…”
mentioning
confidence: 92%
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“…In some studies, authors described that the inoculated bacteria was isolated from blood cultures of patients suffering from the severe pulmonary form of leptospirosis [53]. The sequence of events culminating in lung hemorrhage is mostly similar in the available models [49,[54][55][56]. The studies describe initial capillary congestion followed by endothelial injury and increasing larger areas of parenchymal hemorrhages within a few days (5-10) after inoculation.…”
Section: Pathophysiology Of Pulmonary Leptospirosis: Experimental Stumentioning
confidence: 99%
“…Silva et al, in 1995, described the sequence of events culminating in multi-organ hemorrhage after intraperitoneal inoculation of a virulent strain of Leptospira interrogans serovar copenhageni in guinea pigs [56]. They suggested that Disseminated Intravascular Coagulation is responsible for the hemorrhagic phenomena that increasingly occur as the disease runs its course.…”
Section: Pathophysiology Of Pulmonary Leptospirosis: Experimental Stumentioning
confidence: 99%