The Hematogenous Production of Dermatomycoses

Fried, Sabrina

doi:10.1001/archderm.1929.02380190101008

Cited by 6 publications

(2 citation statements)

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“…This general principle receives confirmation by somewhat similar experiments on rabbits performed by Fried and Segal(1929). An area on the back of the animal was shaved and scarified, the animal was then wrapped in a blanket, and emulsions from cultures of Trichophyton gypseum were injected intravenously.…”

Section: The Dmmatophytesmentioning

confidence: 70%

“…While there is no doubt that the dermatophytes are well adapted to parasitise the skin, the balance of evidence indicates that they are unable to parasitise other organs of the body. Some of the earlier experiments on this point which are summarised briefly by Fried and Segal (1929) appear inconclusive, but recent experiments indicate that the dermatophytes are unable to attack internal organs. P. H. GREGORY Rousseu, Urbain and Barotte (1926) injected large doses of Achorion and Microspan spores into guinea-pigs.…”

Section: The Dmmatophytesmentioning

confidence: 99%

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The Dermatophytes

Gregory¹

1935

Biological Reviews

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Summary. The dermatophytes are a group of fungi which parasitise animals by invading the keratinised portions of the epidermis. They appear to be unable to attack internal organs and are apparently dermatotropic. Ringworm in its various forms is a primary localised dermatophyte infection. The concept of the activity of the dermatophytes has been enlarged by the recognition that they can also determine secondary non‐parasitic skin lesions on distant parts of the body. Several records of isolations of these fungi from the blood indicate that spores may be carried from the primary lesion to other parts of the body by means of the blood stream. Hairs infected by certain species of dermatophytes show a green fluorescence in ultra‐violet light not possessed by uninfected hairs. This phenomenon can be utilised to detect infected hairs among normal ones. The fluorescence is due to a water‐soluble substance which can be extracted from infected hairs. The wealth of spores and other organs produced in cultures on certain animal and vegetable media suggests that these fungi have a natural saprophytic stage in their life history. It is also possible that the saprophytic stage occurs on naturally infected hairs after they fall from the animal body. The dermatophytes in culture are subject to variation. The particular irreversible degenerative mutation known as “pleomorphism” can take place in isolates derived from either a single aleuriospore or a single fuseau. Pleomorphism appears to be due to a toxic action on the organism of monosaccharides and disaccharides. In media containing polysaccharides pleomorphism is not observed. Asci have been reported by several workers. While certain of these records appear to be unsubstantiated, others point to an affinity between the dermatophytes and the Gymnoascaceae. The classification of the 200 or more species is in a state of chaos. The newer systems show few advantages over Sabouraud's revised classification.

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Section: The Dmmatophytesmentioning

confidence: 70%

Section: The Dmmatophytesmentioning

confidence: 99%