The gut signals to AGRP-expressing cells of the pituitary to control glucose homeostasis

Liu, Shunmei; Ifebi, Bruno; Johnson, Fred A.; Xu, Alison; Ho, Jacquelin; Yang, Yunlei; Schwartz, Gary J.; Jo, Young Hwan; Chua, Streamson C.

doi:10.1172/jci164185

Cited by 4 publications

(5 citation statements)

References 82 publications

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“…Recently, Liu et al 5 . demonstrated that cells in the pituitary gland express an AGRP splice variant crucial for modulating systemic glucose metabolism in non‐genetically obese mice 5 .…”

Section: Figurementioning

confidence: 99%

“…Next, to examine whether suppression of AGRP‐B cells affects glucose tolerance, Liu et al 5 . performed experiments in two murine models; Agrp‐B KO mice and AGRP‐B silenced mice.…”

Section: Figurementioning

confidence: 99%

“…Recently, Liu et al . 5 demonstrated that cells in the pituitary gland express an AGRP splice variant crucial for modulating systemic glucose metabolism in non‐genetically obese mice 5 . They first searched a public genome database and recognized that there are three variants, originating in the mouse Agrp gene, which differ in the 5′‐untranslated regions (UTRs); AGRP‐A, AGRP‐B, and AGRP‐C.…”

mentioning

confidence: 99%

“…Next, to examine whether suppression of AGRP‐B cells affects glucose tolerance, Liu et al . 5 performed experiments in two murine models; Agrp‐B KO mice and AGRP‐B silenced mice. First, they fed 2–3‐month‐old Agrp‐B KO mice and wild‐type mice a high‐fat diet (HFD) for 4 weeks and then performed glucose tolerance tests.…”

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confidence: 99%

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Pituitary gland agouti‐related peptide cells: Novel player controlling glucose metabolism

Takahashi,

Katagiri

2023

J of Diabetes Invest

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Section: Figurementioning

confidence: 99%

“…Next, to examine whether suppression of AGRP‐B cells affects glucose tolerance, Liu et al 5 . performed experiments in two murine models; Agrp‐B KO mice and AGRP‐B silenced mice.…”

Section: Figurementioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Pituitary gland agouti‐related peptide cells: Novel player controlling glucose metabolism

Takahashi,

Katagiri

2023

J of Diabetes Invest

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“…Apart from incretins, other postprandial signals have also been involved in regulating glucose and lipid metabolism via the CNS. For instance, FGF19, a postprandial enterokine that has hypoglycemic effects, elicits its effects by modulating both hypothalamic and brainstem neuronal populations to improve glucose homeostasis [ 289 , 290 , 291 , 292 ]. Amylin’s effects on food intake and body weight were demonstrated to be dependent on modulation of brainstem neuronal signaling, specifically lateral dorsal tegmental nucleus, resulting in increased SNS activity to BAT [ 293 ].…”

Section: Crosstalk Between Hypothalamic and Brainstem Nuclei With Met...mentioning

confidence: 99%

Neurochemical Basis of Inter-Organ Crosstalk in Health and Obesity: Focus on the Hypothalamus and the Brainstem

Haspula

Cui

2023

Cells

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Precise neural regulation is required for maintenance of energy homeostasis. Essential to this are the hypothalamic and brainstem nuclei which are located adjacent and supra-adjacent to the circumventricular organs. They comprise multiple distinct neuronal populations which receive inputs not only from other brain regions, but also from circulating signals such as hormones, nutrients, metabolites and postprandial signals. Hence, they are ideally placed to exert a multi-tier control over metabolism. The neuronal sub-populations present in these key metabolically relevant nuclei regulate various facets of energy balance which includes appetite/satiety control, substrate utilization by peripheral organs and glucose homeostasis. In situations of heightened energy demand or excess, they maintain energy homeostasis by restoring the balance between energy intake and expenditure. While research on the metabolic role of the central nervous system has progressed rapidly, the neural circuitry and molecular mechanisms involved in regulating distinct metabolic functions have only gained traction in the last few decades. The focus of this review is to provide an updated summary of the mechanisms by which the various neuronal subpopulations, mainly located in the hypothalamus and the brainstem, regulate key metabolic functions.

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AgRP neurons are not indispensable for body weight maintenance in adult mice

et al. 2023

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The gut signals to AGRP-expressing cells of the pituitary to control glucose homeostasis

Abstract: Departments of Medicine (1), Neuroscience (2) and Molecular Pharmacology (3)

Cited by 4 publications

References 82 publications

Pituitary gland agouti‐related peptide cells: Novel player controlling glucose metabolism

Pituitary gland agouti‐related peptide cells: Novel player controlling glucose metabolism

Neurochemical Basis of Inter-Organ Crosstalk in Health and Obesity: Focus on the Hypothalamus and the Brainstem

AgRP neurons are not indispensable for body weight maintenance in adult mice

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