The Gut Microbiota in Celiac Disease and probiotics

Chibbar, Richa; Dieleman, Levinus A.

doi:10.3390/nu11102375

Cited by 99 publications

(76 citation statements)

References 118 publications

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“…There is a growing body of evidence that exposure to gliadin induces an increased zonulin release which determines the opening of the tight junctions, thereby affecting intestinal barrier integrity. This, in turn, enhances the inflammatory response that contributes to CD pathogenesis and disease progression [165,166].…”

Section: Can Fecal Mirnas Be Celiac Disease Biomarkers Interacting Wimentioning

confidence: 99%

“…and Leuconostoc compared to the normal population [163,175,[177][178][179][180][181][182][183][184][185]. The overall composition and dynamic of gut microbiota in CD patients were reviewed elsewhere [165,[173][174][175][176]185,186]. Although there are ecological differences in the upper and lower part of the intestinal tract that influence the microbiota composition, the bacterial signatures detected in biopsies and feces of CD patients were found to be correlated [179,188].…”

Section: Can Fecal Mirnas Be Celiac Disease Biomarkers Interacting Wimentioning

confidence: 99%

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Fecal microRNAs as Innovative Biomarkers of Intestinal Diseases and Effective Players in Host-Microbiome Interactions

Sarshar

Scribano

Ambrosi

et al. 2020

Cancers

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Over the past decade, short non-coding microRNAs (miRNAs), including circulating and fecal miRNAs have emerged as important modulators of various cellular processes by regulating the expression of target genes. Recent studies revealed the role of miRNAs as powerful biomarkers in disease diagnosis and for the development of innovative therapeutic applications in several human conditions, including intestinal diseases. In this review, we explored the literature and summarized the role of identified dysregulated fecal miRNAs in intestinal diseases, with particular focus on colorectal cancer (CRC) and celiac disease (CD). The aim of this review is to highlight one fascinating aspect of fecal miRNA function related to gut microbiota shaping and bacterial metabolism influencing. The role of miRNAs as “messenger” molecules for inter kingdom communications will be analyzed to highlight their role in the complex host-bacteria interactions. Moreover, whether fecal miRNAs could open up new perspectives to develop novel suitable biomarkers for disease detection and innovative therapeutic approaches to restore microbiota balance will be discussed.

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Section: Can Fecal Mirnas Be Celiac Disease Biomarkers Interacting Wimentioning

confidence: 99%

Section: Can Fecal Mirnas Be Celiac Disease Biomarkers Interacting Wimentioning

confidence: 99%

Fecal microRNAs as Innovative Biomarkers of Intestinal Diseases and Effective Players in Host-Microbiome Interactions

Sarshar

Scribano

Ambrosi

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…They are able to modulate intestinal barrier function and contribute to the development of protective/tolerogenic immune response (96,97). The correlation between CD and intestinal dysbiosis has been described by several groups (98)(99)(100). Indeed, gut microbiota has been shown to contribute to CD pathogenesis by (1) controlling the digestion of gluten peptides therefore generating toxic and tolerogenic peptides (99,101,102); (2) modulating the intestinal permeability (45,(102)(103)(104); (3) driving the proper formation and differentiation of mucosal epithelium (99,105); (4) regulating the expression of pro-inflammatory or anti-inflammatory cytokines (99,106).…”

Section: Probioticsmentioning

confidence: 99%

Celiac Disease and Non-celiac Wheat Sensitivity: State of Art of Non-dietary Therapies

2020

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Gluten related disorders (GRD), which include celiac disease, non-celiac wheat sensitivity and wheat allergy are heterogeneous conditions triggered by ingestion of glutencontaining grains. Together, their prevalence is estimated to be ∼5% in the general population, however, in the last years the number of diagnoses has been rapidly increasing. To this day, the gold standard treatment for these disorders is the complete removal of gluten-containing grains from the diet. Although this therapy results effective in the majority of patients, up to 30% of individuals affected by GRD continue to present persistent symptoms. In addition, gluten-free diet has been shown to have poor nutritional quality and to cause a socioeconomic burden in patients' quality of life. In order to respond to these issues, the scientific community has been focusing on finding additional and adjuvant non-dietary therapies. In this review, we focus on two main gluten related disorders, celiac disease and non-celiac wheat sensitivity. We delineate the actual knowledge about potential treatments and their relative efficacy in pre-clinical and clinical trials.

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“…Various chronic disorders such as inflammatory bowel disease [13], and type 1 diabetes [14] have been shown to be associated with alterations in the gut microbial composition. Recent studies have also suggested that intestinal dysbiosis may play a role in the pathogenesis of coeliac disease [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications

et al. 2020

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Purpose Although genetic predisposition and exposure to dietary gluten are considered necessary triggers for the development of coeliac disease, alterations in the gut microbial composition may also contribute towards the pathogenesis of coeliac disease. This review aims to provide an overview of the available data on the potential mechanisms through which the gut microbiota plays a role in the causation of coeliac disease and to discuss the potential therapeutic strategies that could diminish the consequences of microbial dysbiosis. Method A search of the literature was performed using the PubMed, Embase, and JSTOR databases; relevant articles were included. Results Recent studies in patients with coeliac disease have reported an increase in the relative amounts of gram negative bacterial genera such as Bacteroides, Prevotella, and Escherichia, and reduced amounts of protective anti-inflammatory bacteria such as Bifidobacteria and Lactobacilli. Dysbiotic microbiota may lead to a dysregulated immune response that may contribute to the pathogenesis of coeliac disease. In infancy, antibiotic use and certain infant feeding practices may lead to alterations in the developing gut microbiota to influence the immune maturation process and predispose to coeliac disease. Conclusion The induction of the intestinal immune system and gluten intolerance may be influenced by the relative abundance of certain microbiota. Factors such as infant feeding practices, diet, antibiotics, and infections, may be involved in the development of coeliac disease due to their influence on gut microbial composition. The efficacy of potential modulators of the gut microbiota such as probiotics, prebiotics, and fecal microbial transplant as adjunctive treatments to gluten-free diet in coeliac disease is unproven and requires further investigation.

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The Gut Microbiota in Celiac Disease and probiotics

Cited by 99 publications

References 118 publications

Fecal microRNAs as Innovative Biomarkers of Intestinal Diseases and Effective Players in Host-Microbiome Interactions

Fecal microRNAs as Innovative Biomarkers of Intestinal Diseases and Effective Players in Host-Microbiome Interactions

Celiac Disease and Non-celiac Wheat Sensitivity: State of Art of Non-dietary Therapies

Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications

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