The growing need to establish a global wastewater surveillance consortium for future pandemic preparedness

Murakami, Michio; Kitajima, Masaaki; Endo, Noriko; Ahmed, Warish; Bernd, Gawlik

doi:10.1093/jtm/taad035

Cited by 5 publications

(1 citation statement)

References 4 publications

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“…Among them, the US, France, and Denmark have further conducted sequencing to identify variants from the aircrafts, serving as an indication of the circulating variants originating from the inbound cities. Although the findings were focused on SARS-CoV-2 monitoring, the studies collectively affirm the feasibility of the approach for monitoring emerging infectious diseases threats, and experts advocate for the establishment of a global wastewater surveillance consortium to promote alignment of methodologies and best practices to facilitate monitoring and data sharing across regions [34].…”

Section: Introductionmentioning

confidence: 99%

Monitoring multi-pathogens and SARS-CoV-2 variants in aircraft and airport wastewater

Tay,

Lee,

Ismail

et al. 2024

Preprint

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Background As global travel resumed in COVID-19 endemicity, the potential of aircraft wastewater monitoring to provide early warning of disease trends for SARS-CoV-2 variants and other infectious diseases, particularly at international air travel hubs, was recognized. We therefore assessed and compared the feasibility of testing wastewater from inbound aircraft and airport terminals for 18 pathogens including SARS-CoV-2 in Singapore, a popular travel hub in Asia. Methods Wastewater samples collected from inbound medium- and long-haul flights and airport terminals were tested for SARS-CoV-2. Next Generation Sequencing (NGS) was carried out on positive samples to identify SARS-CoV-2 variants. Airport and aircraft samples were further tested for 17 other pathogens through quantitative reverse transcription polymerase chain reaction (RT-qPCR). Results The proportion of SARS-CoV-2-positive samples and the average virus load was higher for wastewater samples from aircraft as compared to airport terminals. Cross-correlation analyses indicated that viral load trends from airport wastewater led local COVID-19 case trends by two to five days. A total of ten variants (44 sub-lineages) were successfully identified from aircraft wastewater and airport terminals, and four variants of interest (VOIs) and one variant under monitoring (VUM) were detected in aircraft and airport wastewater 18-31 days prior to detection in local clinical cases. The detection of five respiratory and four enteric viruses in aircraft wastewater samples further underscores the potential to expand aircraft wastewater to monitoring pathogens beyond SARS-CoV-2. Conclusion Our findings demonstrate the feasibility of aircraft wastewater testing for monitoring infectious diseases threats, potentially detecting signals before clinical cases are reported. The triangulation of similar datapoints from aircraft wastewater of international travel nodes could therefore serve as a useful early warning system for global health threats.

show abstract

Section: Introductionmentioning

confidence: 99%

Monitoring multi-pathogens and SARS-CoV-2 variants in aircraft and airport wastewater

Tay,

Lee,

Ismail

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

COVID-19 monitoring with sparse sampling of sewered and non-sewered wastewater in urban and rural communities

Wannigama,

Amarasiri,

Hongsing

et al. 2023

iScience

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Usefulness of aircraft and airport wastewater for monitoring multiple pathogens including SARS-CoV-2 variants

Tay,

Lee,

Ismail

et al. 2024

Journal of Travel Medicine

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Background As global travel resumed in COVID-19 endemicity, the potential of aircraft wastewater monitoring to provide early warning of disease trends for SARS-CoV-2 variants and other infectious diseases, particularly at international air travel hubs, was recognised. We therefore assessed and compared the feasibility of testing wastewater from inbound aircraft and airport terminals for 18 pathogens including SARS-CoV-2 in Singapore, a popular travel hub in Asia. Methods Wastewater samples collected from inbound medium- and long-haul flights and airport terminals were tested for SARS-CoV-2. Next Generation Sequencing (NGS) was carried out on positive samples to identify SARS-CoV-2 variants. Airport and aircraft samples were further tested for 17 other pathogens through quantitative reverse transcription polymerase chain reaction (RT-qPCR). Results The proportion of SARS-CoV-2-positive samples and the average virus load was higher for wastewater samples from aircraft as compared to airport terminals. Cross-correlation analyses indicated that viral load trends from airport wastewater led local COVID-19 case trends by two to five days. A total of ten variants (44 sub-lineages) were successfully identified from aircraft wastewater and airport terminals, and four variants of interest (VOIs) and one variant under monitoring (VUM) were detected in aircraft and airport wastewater 18–31 days prior to detection in local clinical cases. The detection of five respiratory and four enteric viruses in aircraft wastewater samples further underscores the potential to expand aircraft wastewater to monitoring pathogens beyond SARS-CoV-2. Conclusion Our findings demonstrate the feasibility of aircraft wastewater testing for monitoring infectious diseases threats, potentially detecting signals before clinical cases are reported. The triangulation of similar datapoints from aircraft wastewater of international travel nodes could therefore serve as a useful early warning system for global health threats.

show abstract

The growing need to establish a global wastewater surveillance consortium for future pandemic preparedness

Cited by 5 publications

References 4 publications

Monitoring multi-pathogens and SARS-CoV-2 variants in aircraft and airport wastewater

Monitoring multi-pathogens and SARS-CoV-2 variants in aircraft and airport wastewater

COVID-19 monitoring with sparse sampling of sewered and non-sewered wastewater in urban and rural communities

Usefulness of aircraft and airport wastewater for monitoring multiple pathogens including SARS-CoV-2 variants

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