The growing importance of materials that prevent microbial adhesion: antimicrobial effect of medical devices containing silver

Monteiro, Douglas Roberto; Gorup, Luiz Fernando; Takamiya, Aline Satie; Ruvollo-Filho, Adhemar Colla; Camargo, Emerson R.; Barbosa, Débora de Barros

doi:10.1016/j.ijantimicag.2009.01.017

Cited by 704 publications

(472 citation statements)

References 61 publications

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“…In dentistry, with the aim to reduce bacterial and fungal adhesion to oral materials and devices, silver particles have been developed and investigated for a range of possible applications, for example, i n c o r p o r a t i o n i n t o d e n t u r e m a t e r i a l s [26] , d e n t a l implants [27] , filling materials [28] and orthodontic adhesives [29] . However, little information is available regarding the antimicrobial effects of silver particles on oral species.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial effects of silver zeolite, silver zirconium phosphate silicate and silver zirconium phosphate against oral microorganisms

Saengmee-anupharb

Srikhirin

Thaweboon

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

Antimicrobial effects of silver zeolite, silver zirconium phosphate silicate and silver zirconium phosphate against oral microorganisms

Saengmee-anupharb

Srikhirin

Thaweboon

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Antimicrobial Coatingsmentioning

confidence: 99%

“…Several antimicrobial surfaces have been described in the literature, including non-antibiotic antimicrobial agents such as silver, salicylic acid, quaternary ammonium compounds, phenol derivatives, chlorhexidine and nitric oxide [3,5,13,33]. However, many of these compounds are associated with anaphylaxis, cytotoxicity or low efficiency [5,13]. These limiting aspects prompt the use of true antibiotics such as vancomycin, tobramycin, cefalozin, teicoplanin, carbenicillin, amoxicillin, penicillin, ampicillin and gentamicin [3,[34][35][36][37], through two different strategies: substance-releasing coating and substance covalent immobilization.…”

Section: Antimicrobial Coatingsmentioning

confidence: 99%

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

et al. 2011

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a b s t r a c tBacterial adhesion to biomaterials remains a major problem in the medical devices field. Antimicrobial peptides (AMPs) are well-known components of the innate immune system that can be applied to overcome biofilm-associated infections. Their relevance has been increasing as a practical alternative to conventional antibiotics, which are declining in effectiveness. The recent interest focused on these peptides can be explained by a group of special features, including a wide spectrum of activity, high efficacy at very low concentrations, target specificity, anti-endotoxin activity, synergistic action with classical antibiotics, and low propensity for developing resistance. Therefore, the development of an antimicrobial coating with such properties would be worthwhile. The immobilization of AMPs onto a biomaterial surface has further advantages as it also helps to circumvent AMPs' potential limitations, such as short half-life and cytotoxicity associated with higher concentrations of soluble peptides. The studies discussed in the current review report on the impact of covalent immobilization of AMPs onto surfaces through different chemical coupling strategies, length of spacers, and peptide orientation and concentration. The overall results suggest that immobilized AMPs may be effective in the prevention of biofilm formation by reduction of microorganism survival post-contact with the coated biomaterial. Minimal cytotoxicity and longterm stability profiles were obtained by optimizing immobilization parameters, indicating a promising potential for the use of immobilized AMPs in clinical applications. On the other hand, the effects of tethering on mechanisms of action of AMPs have not yet been fully elucidated. Therefore, further studies are recommended to explore the real potential of immobilized AMPs in health applications as antimicrobial coatings of medical devices.

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“…[1,2] This has stimulated a search for polymers and other materials that resist the attachment of pathogens, or that exhibit antibacterial or bacteriostatic properties. [3][4][5][6][7][8][9] Materials discovery is now increasingly been carried out using high throughput synthesis and characterization methods so that novel, useful areas of materials property space can be identified. [10][11][12][13][14][15][16][17][18][19] While high throughput experimental techniques can dramatically accelerate new materials discovery, it is essential that complementary computational and informatics techniques are also are also be used.…”

Section: Introductionmentioning

confidence: 99%

Modelling and Prediction of Bacterial Attachment to Polymers

Epa

Hook

Chang

et al. 2013

Adv Funct Materials

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Infection by pathogenic bacteria on implanted and indwelling medical devices during surgery causes large morbidity and mortality worldwide. Attempts to ameliorate this important medical issue have included development of antimicrobial surfaces on materials, 'no touch' surgical procedures, and development of materials with inherent low pathogen attachment.The search for new materials is increasingly being carried out by high throughput methods.Efficient methods for extracting knowledge from these large data sets are essential. We used data from a large polymer microarray exposed to three clinical pathogens to derive robust and predictive machine-learning models of pathogen attachment. The models could predict pathogen attachment for the polymer library quantitatively. The models also successfully 22222222224222 predicted pathogen attachment for a second-generation library, and identified polymer surface chemistries that enhance or diminish pathogen attachment.

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The growing importance of materials that prevent microbial adhesion: antimicrobial effect of medical devices containing silver

Cited by 704 publications

References 61 publications

Antimicrobial effects of silver zeolite, silver zirconium phosphate silicate and silver zirconium phosphate against oral microorganisms

Antimicrobial effects of silver zeolite, silver zirconium phosphate silicate and silver zirconium phosphate against oral microorganisms

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

Modelling and Prediction of Bacterial Attachment to Polymers

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