Bjoern von Einem, Judith Eschbach, Martin Kiechle, Anke Wahler, Dietmar R. Thal, Pamela J. McLean, Jochen H. Weishaupt, Albert C. Ludolph, Christine A.F. von Arnim, Karin M. Danzer
Abstract:Several age-related neurodegenerative disorders are associated with protein misfolding and aggregation of toxic peptides. α-synuclein (α-syn) aggregation and the resulting cytotoxicity is a hallmark of Parkinson's disease (PD) as well as dementia with Lewy bodies. Rising evidence points to oligomeric and pre-fibrillar forms as the pathogenic species, and oligomer secretion seems to be crucial for the spreading and progression of PD pathology. Recent studies implicate that dysfunctions in endolysosomal/autophag…
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