The Global Burden of Early-Onset Biliary Tract Cancer: Insight From the Global Burden of Disease Study 2019

Danpanichkul, Pojsakorn; Ng, Cheng H.; Tan, Darren J.H.; Muthiah, Mark D.; Kongarin, Siwanart; Srisurapanont, Karan; Kanjanakot, Yatawee; Duangsonk, Kwanjit; Huang, Daniel Q.; Suzuki, Hiroyuki; Harnois, Denise M.; Yang, Ju D.; Noureddin, Mazen; Wijarnpreecha, Karn

doi:10.1016/j.jceh.2023.101320

Cited by 7 publications

(1 citation statement)

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“…In Europe, the highest incidence was reported in Italy (3.4 cases per 100,000) [3]. Gene alterations involving IDH (isocitrate dehydrogenase gene), FGFR (fibroblast growth factor receptor), BRAF (v-RAF murine sarcoma viral oncogene homolog B1), HER2 (human epidermal growth factor receptor 2) can decisively influence the proliferation and development of cholangiocarcinoma [5]. Along with the use of immune checkpoint inhibitors in this location, the need to identify effective predictive biomarkers also appeared, but research in this area is still ongoing.…”

Section: Introductionmentioning

confidence: 99%

Options in Targeted Therapy for Advanced Cholangiocarcinoma: A 2024 Update

Oprescu Macovei,

Venter,

Makkai

et al. 2024

Cureus

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Bile duct carcinomas have a different prognosis and genetic profile depending on their location; intrahepatic/extrahepatic or at the level of the gallbladder. Although in recent years there have been important advances in first-line therapy, second-line therapy in cholangiocarcinoma does not currently have a standard. Therefore at this level, there is an acute need for personalized treatment. The present article is a narrative review that aims to list the newest targeted therapeutic options for this type of cancer, based on identified genetic alterations. The literature selected for analysis includes phase 2 or 3 studies with targeted therapy in this disease and original articles no older than three years that describe the prevalence of the most common gene alterations in this type of cancer. PubMed/Medline, Scopus, and Clarivate-Web of Science databases were searched and keywords such as "cholangiocarcinoma," "biliary cancer," "targeted therapy," "gene amplifications," and "mutations" were used. This narrative review was designed taking into account the SANRA (Scale for the Assessment of Narrative Review Articles) criteria. The conclusions lead to the fact that next-generation sequencing testing is of particular usefulness in cholangiocarcinoma. Bile duct cancers are rich in targetable genetic alterations, and their treatment is in constant change, although much of the current data comes from phase II studies. There is a great need for the current options to be analyzed in phase III studies. Hence, the need of the oncological community to stay informed about targeted treatment options for cholangiocarcinoma is supported by the present article.

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Section: Introductionmentioning

confidence: 99%