volume 223, issue 2, P252-262 2010
DOI: 10.1002/path.2798
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Abstract: Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the intestinal tract, known to be notoriously refractory to conventional chemotherapy or radiation. It is an ideal solid tumor model to apply our understanding from aberrant signal transduction to drug development, since nearly all tumors have a mutation in the KIT or, less often, PDGFRA or BRAF gene. The constitutively activated KIT and PDGFRA oncoproteins serve as crucial diagnostic and therapeutic targets. The discovery of oncogenic KIT ac…

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