The Germinal Zones of the Basal Ganglia But Not the Septum Generate GABAergic Interneurons for the Cortex

Rubin, Anna Noren; Alfonsi, Fabienne; Humphreys, Michael P.; Choi, Christina K. P.; Rocha, Susana; Kessaris, Nicoletta

doi:10.1523/jneurosci.6178-09.2010

Cited by 80 publications

(123 citation statements)

References 62 publications

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“…This might be due to the fact that many cells that are fated to become PV-expressing cells have not turned on the expression of this calcium-binding protein at P14, when we analyzed these experiments (Soriano et al, 1992). Third, the other regions containing Dbx1-expressing progenitors do not seem to produce GABAergic interneurons (Bielle et al, 2005;Rubin et al, 2010). Finally, it has been recently shown that a small fraction of PVϩ cortical interneurons derive from Shh-expressing cells in the subpallium (Flandin et al, 2010).…”

Section: Discussionmentioning

confidence: 96%

“…Moreover, recent experimental evidence indicates that the subpallial septum is not a source of cortical GABAergic interneurons (Rubin et al, 2010). In contrast, the POA has been previously shown to give rise to small populations of cortical and amygdalar GABAergic interneurons (Gelman et al, 2009;Hirata et al, 2009), which prompted us to analyze this region in more detail.…”

Section: The Embryonic Poa Is the Origin Of Dbx1-derived Cortical Intmentioning

confidence: 98%

“…The medial ganglionic eminence (MGE) gives rise to several classes of interneurons that can be grouped into two broad categories: fast-spiking (FS) interneurons that express the calcium-binding protein parvalbumin (PV) and non-fast-spiking interneurons that contain the neuropeptide somatostatin (SST) (Xu et al, 2004;Butt et al, 2005;Fogarty et al, 2007;Miyoshi et al, 2007Miyoshi et al, , 2010Rubin et al, 2010). The caudal ganglionic eminence (CGE) also produces different classes of interneurons that belong to two large groups: bipolar interneurons that express vasoactive intestinal peptide (VIP) and/or the calcium-binding protein calretinin (CR), and multipolar interneurons that contain neuropeptide Y (NPY) or Reelin (Ló pez-Bendito et al, 2004;Xu et al, 2004;Butt et al, 2005;Lee et al, 2010;Miyoshi et al, 2010;Vucurovic et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Collectively, the MGE and the CGE are the origin of Ͼ90% of the GABAergic interneurons in the cerebral cortex (Wonders and Anderson, 2006;Batista-Brito and Fishell, 2009;Rubin et al, 2010). Thus, one question that remains unsolved is the source of the remaining ϳ10% of cortical interneurons that do not seem to derive from progenitor cells in the MGE and CGE.…”

Section: Introductionmentioning

confidence: 99%

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A Wide Diversity of Cortical GABAergic Interneurons Derives from the Embryonic Preoptic Area

Gelman¹,

Griveau²,

Dehorter³

et al. 2011

J. Neurosci.

160

155

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GABA-containing (GABAergic) interneurons comprise a very heterogeneous group of cells that are crucial for cortical function. Different classes of interneurons specialize in targeting specific subcellular domains of excitatory pyramidal cells or other interneurons, which provides cortical circuits with an enormous capability for information processing. As in other regions of the CNS, cortical interneuron diversity is thought to emerge from the genetic specification of different groups of progenitor cells within the subpallium. Most cortical interneurons originate from two main regions, the medial and the caudal ganglionic eminences (MGE and CGE, respectively). In addition, it has been shown that progenitors in the embryonic preoptic area (POA) also produce a small population of cortical GABAergic interneurons. Here, we show that the contribution of the POA to the complement of cortical GABAergic interneurons is larger than previously believed. Using genetic fate mapping and in utero transplantation experiments, we demonstrate that Dbx1-expressing progenitor cells in the POA give rise to a small but highly diverse cohort of cortical interneurons, with some neurochemical and electrophysiological characteristics that were previously attributed to MGE-or CGEderived interneurons. There are, however, some features that seem to distinguish POA-derived interneurons from MGE-or CGE-derived cells, such as their preferential laminar location. These results indicate that the mechanisms controlling the specification of different classes of cortical interneurons might be more complex than previously expected. Together with earlier findings, our results also suggest that the POA generates nearly 10% of the GABAergic interneurons in the cerebral cortex of the mouse.

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Section: Discussionmentioning

confidence: 96%

Section: The Embryonic Poa Is the Origin Of Dbx1-derived Cortical Intmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Wide Diversity of Cortical GABAergic Interneurons Derives from the Embryonic Preoptic Area

Gelman¹,

Griveau²,

Dehorter³

et al. 2011

J. Neurosci.

160

155

View full text Add to dashboard Cite

show abstract

“…In comparison, Nkx2.1 is expressed solely in the MGE, and the knockout exhibits only a 50% decrease in interneuron numbers [25,26]. More recently, the contribution of interneurons from the CGE has been examined by genetic fate mapping studies indicating that approximately 30% of cortical interneurons are produced within this area [27,28]. …”

Section: Cortical Interneuron Originmentioning

confidence: 99%

Neurons on the Move: Migration and Lamination of Cortical Interneurons

et al. 2012

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The modulation of cortical activity by GABAergic interneurons is required for normal brain function and is achieved through the immense level of heterogeneity within this neuronal population. Cortical interneurons share a common origin in the ventral telencephalon, yet during the maturation process diverse subtypes are generated that form the characteristic laminar arrangement observed in the adult brain. The long distance tangential and short-range radial migration into the cortical plate is regulated by a combination of intrinsic and extrinsic signalling mechanisms, and a great deal of progress has been made to understand these developmental events. In this review, we will summarize current findings regarding the molecular control of subtype specification and provide a detailed account of the migratory cues influencing interneuron migration and lamination. Furthermore, a dysfunctional GABAergic system is associated with a number of neurological and psychiatric conditions, and some of these may have a developmental aetiology with alterations in interneuron generation and migration. We will discuss the notion of additional sources of interneuron progenitors found in human and non-human primates and illustrate how the disruption of early developmental events can instigate a loss in GABAergic function.

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Radial glia in the ventral telencephalon

García

Harwell

2017

FEBS Letters

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The ventral telencephalon is the developmental origin of the basal ganglia and the source of neuronal and glial cells that integrate into developing circuits in other areas of the brain. Radial glia in the embryonic subpallium give rise to an enormous diversity of mature cell types, either directly or through other transit-amplifying progenitors. Here, we review current knowledge about these subpallial neural stem cells and their progeny, focusing on the period of neurogenesis. We describe their cell biological features and the extrinsic and intrinsic molecular codes that guide their fate specification in defined temporal and spatial sequences. We also discuss the role of clonal lineage in the organization and specification of mature neurons.

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The Germinal Zones of the Basal Ganglia But Not the Septum Generate GABAergic Interneurons for the Cortex

Cited by 80 publications

References 62 publications

A Wide Diversity of Cortical GABAergic Interneurons Derives from the Embryonic Preoptic Area

A Wide Diversity of Cortical GABAergic Interneurons Derives from the Embryonic Preoptic Area

Neurons on the Move: Migration and Lamination of Cortical Interneurons

Radial glia in the ventral telencephalon

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