Annalisa Izzo, Kinga Kamieniarz-Gdula, Fidel Ramírez, Nighat Noureen, Jop Kind, Thomas Manke, Bas van Steensel, Robert Schneider
Abstract:Human cells contain five canonical, replication-dependent somatic histone H1 subtypes (H1.1, H1.2, H1.3, H1.4, and H1.5). Although they are key chromatin components, the genomic distribution of the H1 subtypes is still unknown, and their role in chromatin processes has thus far remained elusive. Here, we map the genomic localization of all somatic replication-dependent H1 subtypes in human lung fibroblasts using an integrative DNA adenine methyltransferase identification (DamID) analysis. We find in general th…
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