2000
DOI: 10.1126/science.287.5461.2185
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Abstract: The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ∼120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quali… Show more

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Cited by 5,362 publications
(3,521 citation statements)
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References 76 publications
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“…The Dgad2 cDNA clone, the G-2 genomic clone (Phillips et al, 1993), both derived from Canton-S, and the genomic sequence in Flybase (Scaffold No AE003641, Ashburner et al, 1999;Adams et al, 2000;Celniker et al, 2002) were identical in sequence. Laboratory strains, Oregon-R and w 1118 , also showed conservation of the Dgad2 sequence.…”
Section: Molecular Analysis Of the Dgad2 Genementioning
confidence: 99%
“…The Dgad2 cDNA clone, the G-2 genomic clone (Phillips et al, 1993), both derived from Canton-S, and the genomic sequence in Flybase (Scaffold No AE003641, Ashburner et al, 1999;Adams et al, 2000;Celniker et al, 2002) were identical in sequence. Laboratory strains, Oregon-R and w 1118 , also showed conservation of the Dgad2 sequence.…”
Section: Molecular Analysis Of the Dgad2 Genementioning
confidence: 99%
“…TBLASTN searches of the published Drosophila melanogaster scaffold sequence (Adams et al, 2000) and Drosophila EST database were performed with different forkhead domain query sequences from Drosophila and vertebrates. Sequences that were interrupted by introns were re-examined using the most closely related forkhead domain sequence as a query sequence, and based upon these alignments, the presence of splicing donor and acceptor sites was verified in the genomic sequence.…”
Section: Experimental Procedures Database Search and Phylogenetic Anamentioning
confidence: 99%
“…The publication of the sequence of the euchromatic portion of the Drosophila melanogaster genome (Adams et al, 2000) has made it possible to complete the survey of forkhead encoding genes from this genetic model organism. We show herein that the Drosophila genome encodes a total of 17 forkhead domain genes.…”
Section: Introductionmentioning
confidence: 99%
“…The four Calymmin prodomains exhibit different degrees of homology to portions of the amino acid sequence of some polypeptides from the databases with unknown functions. These peptides included the Drosophila melanogaster cg6639, a serine protease-like peptide, and cg11581 proteins (Adams et al, 2000), and the Mycobacterium tuberculosis hypothetical 56.9-kDa protein cy10h4.20c (Cole et al, 1998), and the M. leprae hypothetical 49.8-kDa protein (Eiglmeier, et al, 1993), both of which also contain forkhead-associated domains (Durocher et al, 1999) at their C terminus ( Fig. 2A).…”
Section: Isolation Of Calymmin Full-length Cdna and Amino Acid Sequenmentioning
confidence: 99%