1994
DOI: 10.1001/archderm.130.2.216
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The genetics of psoriasis

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Cited by 56 publications
(18 citation statements)
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“…While PsV has a prevalence of up to 3% in populations of European ancestry (Bowcock and Barker, 2003; Griffiths and Barker, 2007), the estimated prevalence of PsA varies from 0.25% to 1% (Gladman et al , 2005). The strong genetic component of PsA is evidenced by the high sibling recurrence risk (λ S ) of 27–47 (Chandran et al , 2009; Gladman et al , 2003; Myers et al , 2005), which is much higher than the estimated λ S =4–11 of PsV (Bhalerao and Bowcock, 1998; Elder et al , 1994), suggesting that PsA patients harbor additional susceptibility loci beside the loci that contribute to risk for PsV. In addition to the significant heritable component, environmental risk factors play an important role for both PsV and PsA.…”
Section: Introductionmentioning
confidence: 99%
“…While PsV has a prevalence of up to 3% in populations of European ancestry (Bowcock and Barker, 2003; Griffiths and Barker, 2007), the estimated prevalence of PsA varies from 0.25% to 1% (Gladman et al , 2005). The strong genetic component of PsA is evidenced by the high sibling recurrence risk (λ S ) of 27–47 (Chandran et al , 2009; Gladman et al , 2003; Myers et al , 2005), which is much higher than the estimated λ S =4–11 of PsV (Bhalerao and Bowcock, 1998; Elder et al , 1994), suggesting that PsA patients harbor additional susceptibility loci beside the loci that contribute to risk for PsV. In addition to the significant heritable component, environmental risk factors play an important role for both PsV and PsA.…”
Section: Introductionmentioning
confidence: 99%
“…While the etiology and mode of inheritance of psoriasis remain unknown, hereditary transmission of psoriasis susceptibility is well established [for recent reviews, see 1, 2, 3]. The strongest candidate for location of a psoriasis susceptibility gene has been a region on chromosome 6p, near the HLA complex, because of the strong, consistent associations reported between psoriasis and certain HLA alleles, particularly B17 and Cw6 [4, 5, 6].…”
Section: Introductionmentioning
confidence: 99%
“…It is estimated that approximately one-third of psoriatic patients have a first-degree relative affected by the disease [48]. Furthermore, the heritability, which denotes the proportion of variability of a trait attributed to a genetic factor, is believed to range from 60% to 90% in psoriasis [49, 50]. …”
Section: Genetic Inheritance Of Psoriasismentioning
confidence: 99%