The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

Abondio, Paolo; Sazzini, Marco; Garagnani, Paolo; Boattini, Alessio; Monti, Daniela; Franceschi, Claudio; Luiselli, Donata; Giuliani, Cristina

doi:10.3390/genes10030222

Cited by 103 publications

(88 citation statements)

References 261 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Single nucleotide polymorphisms (SNPs) were analyzed using a custom Illumina HumanCoreExome array 28 . APOE haplotypes were defined by rs429358 and rs7412 38 . Following a previous report, 39 three additional SNPs were analyzed: CR1 (rs3818361), CLU (rs11136000), and PICALM (rs3851179).…”

Section: Methodsmentioning

confidence: 99%

Adherence to a Mediterranean diet and cognitive function in the Age‐Related Eye Disease Studies 1 & 2

Keenan

Agrón

Mares

et al. 2020

Alzheimer's & Dementia

View full text Add to dashboard Cite

Introduction The objective was to determine whether closer adherence to the alternative Mediterranean Diet (aMED) was associated with altered cognitive function. Methods Observational analyses of participants (n = 7,756) enrolled in two randomized trials of nutritional supplements for age‐related macular degeneration: Age‐Related Eye Disease Study (AREDS) and AREDS2. Results Odds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 (P = .0001) for Modified Mini‐Mental State (<80) and 0.56 (P = .001) for composite score in AREDS, and 0.56 for Telephone Interview Cognitive Status‐Modified (<30) and 0.48 for composite score (each P < .0001) in AREDS2. Fish intake was associated with higher cognitive function. In AREDS2, rate of cognitive decline over 5 to 10 years was not significantly different by aMED but was significantly slower (P = .019) with higher fish intake. Discussion Closer Mediterranean diet adherence was associated with lower risk of cognitive impairment but not slower decline in cognitive function. Apolipoprotein E (APOE) haplotype did not influence these relationships.

show abstract

Section: Methodsmentioning

confidence: 99%

Adherence to a Mediterranean diet and cognitive function in the Age‐Related Eye Disease Studies 1 & 2

Keenan

Agrón

Mares

et al. 2020

Alzheimer's & Dementia

View full text Add to dashboard Cite

show abstract

“…A number of recent reviews discuss the structure and function of APOE (e.g. Abondio et al, 2019;Marais, 2019). However, as APOE biology in the brain is distinct from that in the periphery, a summary of its brain-relevant functions here provides helpful context for understanding subsequent discussions of its sex-specific role in LOAD.…”

Section: Brain-specific Functions Of Apoementioning

confidence: 99%

Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders

Gamache

Yun

Chiba‐Falek

2020

Disease Models &Amp; Mechanisms

View full text Add to dashboard Cite

The importance of apolipoprotein E (APOE) in late-onset Alzheimer's disease (LOAD) has been firmly established, but the mechanisms through which it exerts its pathogenic effects remain elusive. In addition, the sex-dependent effects of APOE on LOAD risk and endophenotypes have yet to be explained. In this Review, we revisit the different aspects of APOE involvement in neurodegeneration and neurological diseases, with particular attention to sex differences in the contribution of APOE to LOAD susceptibility. We discuss the role of APOE in a broader range of age-related neurodegenerative diseases, and summarize the biological factors linking APOE to sex hormones, drawing on supportive findings from rodent models to identify major mechanistic themes underlying the exacerbation of LOAD-associated neurodegeneration and pathology in the female brain. Additionally, we list sex-by-genotype interactions identified across neurodegenerative diseases, proposing APOE variants as a shared etiology for sex differences in the manifestation of these diseases. Finally, we present recent advancements in ‘omics’ technologies, which provide a new platform for more in-depth investigations of how dysregulation of this gene affects the development and progression of neurodegenerative diseases. Collectively, the evidence summarized in this Review highlights the interplay between APOE and sex as a key factor in the etiology of LOAD and other age-related neurodegenerative diseases. We emphasize the importance of careful examination of sex as a contributing factor in studying the underpinning genetics of neurodegenerative diseases in general, but particularly for LOAD.

show abstract

“…The human APOE gene has three common allelic variants E2, E3, and E4 encoded on chromosome 19. Depending on the genetic variability, the gene has been ascribed significant positive and negative health effects such as longevity and shortened lifespan, neurological and psychosomatic disorders, cognitive decline and Alzheimer disease, altered lipoprotein profile, atherosclerosis and cardiovascular disease, type II diabetes, changes in the immune response, oxidative stress, quality of life, physical activity, and obesity [1][2][3][4]. At large, E4 has been ascribed unfavourable health outcomes and E2 healthpromoting effects [1,[5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

APOE – a genetic marker of comorbidity in subjects with morbid obesity

2020

View full text Add to dashboard Cite

Background: In population-based studies, the genetic variability of the APOE E alleles have been associated with health outcomes. Health problems are common in subjects with obesity. This study explored associations between the APOE E alleles and comorbidity in subjects with morbid obesity. Methods: The study included consecutive subjects referred for evaluation of bariatric surgery with morbid obesity (defined as BMI > 40 or > 35 kg/m 2 with complications related to obesity). The subjects followed a conservative weight loss program for 6 months before surgery and had a follow-up visit 12 months after surgery. Demographic data and a set psychosomatic scores (musculoskeletal pain, WHO-5 Well-Being Index, Rosenberg Self-Esteem Scale, Hopkins Symptom Checklist 10; Epworth Sleepiness Scale, and Fatigue Severity Scale) were collected, and blood samples were analysed for haematological and biochemical parameters and APOE alleles. Results: One hundred and forty subjects (men/women: 32 (23%)/108 (77%) with mean age 43.0 (SD 8.7) years and BMI 42.1 (SD 3.8) kg/m 2 were included. One hundred and eight and 92 subjects had data after conservative treatment and 12 months after surgery, respectively. The prevalence of the APOE alleles were: E2E2: 1 (0.7%), E2E3: 13 (9.3%), E2E4: 4 (2.9%), E3E3: 71 (50.7%), E3E4: 47 (33.6%), and E4E4: 4 (2.9%). The prevalence rates were as anticipated in a Norwegian population. The weight loss during conservative treatment and after bariatric surgery was independent of E allele variability. E2 was associated with a significant or clear trend toward improvement of all psychosomatic disorders. There was a significant fall in CRP during the two treatment periods with weight loss. E2 and E4 were significantly associated with high and low CRP, respectively, but no associations were seen between CRP and comorbidity. Conclusions: The most marked finding was the association between E2 and improvement of all psychosomatic disorders. The positive and negative associations between CRP and E2 and E4, respectively, could indicate effects on inflammation and immunological reactions.

show abstract

The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

Cited by 103 publications

References 261 publications

Adherence to a Mediterranean diet and cognitive function in the Age‐Related Eye Disease Studies 1 & 2

Adherence to a Mediterranean diet and cognitive function in the Age‐Related Eye Disease Studies 1 & 2

Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders

APOE – a genetic marker of comorbidity in subjects with morbid obesity

Contact Info

Product

Resources

About