The genetic epidemiology of psoriasis vulgaris in Chinese Han

Zhang, Xuejun; Wang, Hongyan; Te‐shao, Hsu; Yang, Sen; Chen, Shanyu

doi:10.1046/j.1365-4362.2002.01596.x

Cited by 50 publications

(57 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Psoriasis is a complex and polygenetic hereditary disease involving genetic risk factors and environmental triggers, and the former usually play decisive roles in the pathogenesis and mechanism of psoriasis [2][3][4]21] . Therefore, it is of great significance to screen and clarify the function of more genetic risk factors or PSORS genes.…”

Section: Discussionmentioning

confidence: 99%

“…The research progresses on genetic epidemiology, and genetics have confirmed that psoriasis is a complex and polygenetic hereditary disease mediated by the cells and molecules of both the innate and adaptive immune systems [2] , and its possible pathogenesis and mechanism consist of the interaction between gene and gene and between gene and environment (stress, trauma, environmental pollution, etc.) [3,4] . Therefore, clarifying the functions of psoriasis susceptibility genes is of great significance for the treatment of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Screening of Skin Lesion-Associated Genes in Patients with Psoriasis by Meta-Integration Analysis

Mei¹,

Mei²

2017

Dermatology

View full text Add to dashboard Cite

Aim: Psoriasis is an inflammatory skin disease, and approximately one quarter of individuals with psoriasis develop painful and debilitating arthritis. As a complex and polygenetic hereditary disease, it is significant to investigate skin lesion-associated genes of psoriasis. Method: In the present study, a total of 3,047 differentially expressed genes between lesional and nonlesional skin of psoriasis patients were screened based on 4 data sets in GEO DataSets. In the following, network module analyses were performed. Result: After calculating the correlation coefficients between eigenvalues of each module and disease status (psoriatic lesion and nonlesion), it was observed that the genes in black and green modules showed a significant correlation in each data set. Consequently, 58 significant characteristic genes of black modules and 74 of green modules were chosen for further analysis. The interaction network of the candidate feature genes was constructed based on the BioGRID, HPRD, and BIND databases, which contained 310 nodes. The mutual relationships of 70 genes, including 28 genes in the black module and 42 genes in the green module, were summarized, and 5 drug molecules related to these 70 factors were detected. Mepacrine and camptothecin were indicated as 2 drugs negatively related to psoriasis. Conclusion: The results suggested a pathogenesis mechanism of psoriasis and indicated novel therapeutic targets for psoriasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Screening of Skin Lesion-Associated Genes in Patients with Psoriasis by Meta-Integration Analysis

Mei¹,

Mei²

2017

Dermatology

View full text Add to dashboard Cite

show abstract

“…The heritability of psoriasis was 71% in first degree relatives and 37% in second degree relatives. 26 …”

Section: Risk Factors Geneticsmentioning

confidence: 99%

Epidemiology and treatment of psoriasis: a Chinese perspective

Pan¹,

Zhang²

2014

PTT

View full text Add to dashboard Cite

Background: Psoriasis is a chronic inflammatory skin disease that has a negative impact on quality of life. Prevalence and management of psoriasis varies among different ethnic groups. Objectives: To evaluate the epidemiology and treatment of psoriasis from a Chinese perspective. Methods: A systematic search was performed on PubMed and the China National Knowledge Infrastructure using the following MeSH terms: "psoriasis" and ("prevalence" or "epidemiology") and "risk factor" and ("management" or "treatment"). The search included all citations from 1975 to 2013. Data were sorted by prevalence, age of onset, sex distribution, type, severity, risk factors, and management and treatment. Severity of psoriasis was classified as mild, moderate, or severe. The studies cited in this review involved Chinese subjects. Results: The prevalence of psoriasis in the People's Republic of China ranged from 0.11% to 0.47%. Genetic and environmental factors played an important role in initiation and exacerbation of psoriasis. Results showed that psoriasis can occur at any age but is more common in young and middle-aged individuals and occurs more often in men and earlier in women. Psoriasis vulgaris accounted for 82.6%-97.1% of psoriasis patients. More than 90% of patients with psoriasis were classified as mild or moderately severe. Risk factors are numerous. Management and treatment was based on classification level. Conclusion:The prevalence of psoriasis in Chinese patients is lower than that in Caucasians. A cold and dry climate, bacterial infection, diet, and stress are important risk factors for developing psoriasis. There are a variety of management and treatment options available. As such, Chinese patients with psoriasis can receive effective, safe, and individualized treatment.

show abstract

“…The mean age at diagnosis has been reported to be between 10 and 11 years of age by a recent large population-based study [ 13 ]. Onset may occur slightly earlier for females [ 14 ], although studies have shown nearly equal male to female prevalence ratios [ 11 , 12 , 15 ]. Onset may also occur earlier in those with a positive family history of psoriasis [ 14 ].…”

mentioning

confidence: 99%

“…Onset may occur slightly earlier for females [ 14 ], although studies have shown nearly equal male to female prevalence ratios [ 11 , 12 , 15 ]. Onset may also occur earlier in those with a positive family history of psoriasis [ 14 ]. Table 20.1 shows a review of worldwide presentation of pediatric psoriasis.…”

mentioning

confidence: 99%

Pediatric Psoriasis

Pepper¹,

Pothiawala²,

Silverberg³

2014

Advances in Psoriasis

View full text Add to dashboard Cite

Psoriasis is a chronic multi-system infl ammatory condition with an autoimmune component. One-third to one-half of cases have onset in childhood. There are a variety of pediatric variant types of psoriasis, including generalized disease, that is similar to adult psoriasis, and types distinctive to childhood, including diaper involvement and pityriasis amiantacea. Pediatric psoriasis is associated with infectious triggers and exacerbation by the Koebner phenomenon. Children with psoriasis may have more of a tendency toward obesity as refl ected by a large waist circumference. More extensive disease in childhood is associated with a poor quality of life. Therapeutics of pediatric psoriasis generally requires a global approach including identifying infectious triggers, addressing health risks including obesity, and psychological support. Prescription care includes application of mid-potency topical corticosteroids and/or calcipotriene, phototherapy with Narrowband UVB or excimer laser. In severe cases, cyclic prescribing of systemic agents for 6-12 months including methotrexate, cyclosporine and etanercept can aid in disease clearance with minimization of side effects.

show abstract

The genetic epidemiology of psoriasis vulgaris in Chinese Han

Abstract: Psoriasis vulgaris follows a pattern of polygenetic or multifactorial inheritance rather than single-gene inheritance.

Cited by 50 publications

References 14 publications

Screening of Skin Lesion-Associated Genes in Patients with Psoriasis by Meta-Integration Analysis

Screening of Skin Lesion-Associated Genes in Patients with Psoriasis by Meta-Integration Analysis

Epidemiology and treatment of psoriasis: a Chinese perspective

Pediatric Psoriasis

Contact Info

Product

Resources

About