The gene network determining development of Drosophila melanogaster mechanoreceptors

Furman, D. P.; Бухарина, Т. А.

doi:10.1016/j.compbiolchem.2009.04.001

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…The CRC determines the functioning of the achaete-scute gene complex (AS-C) as well as the overall macrochaete morphogenesis. 5,[10][11][12] In addition to AS-C, the key element of the CRC, this circuit also contains the genes hairy, senseless (sens), charlatan (chn), daughterless (da), extramacrochaete (emc), groucho (gro), and scratch (scrt) (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

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A model study of the morphogenesis ofD. melanogastermechanoreceptors: The central regulatory circuit

Golubyatnikov

Бухарина

Furman

2015

J. Bioinform. Comput. Biol.

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Macrochaetes (large bristles) are sensor organs of the Drosophila peripheral nervous system with a function of mechanoreceptors. An adult mechanoreceptor comprises four specialized cells: shaft (trichogen), socket (tormogen), neuron, and glial cell (thecogen). All these cells originate from a single cell, the so-called sensor organ precursor (SOP) cell. Separation of the SOP cell from the encompassing cells of the imaginal disc initiates a multistage process of sensory organ development. A characteristic feature of the SOP cell is the highest amount of the proneural proteins AS-C as compared with the encompassing ectodermal cells. The accumulation of proneural proteins and maintenance of their amount in the SOP cell at a necessary level is provided by the gene network with the achaete-scute gene complex (AS-C) as its key component. The activity of this complex is controlled by the central regulatory circuit (CRC). The CRC comprises the genes hairy, senseless (sens), charlatan (chn), scratch (scrt), daughterless (da), extramacrochaete (emc), and groucho (gro), coding for the transcription factors involved in the system of direct links and feedbacks and implementation of activation-repression relationships between the CRC components. The gene phyllopod (phyl), involved in degradation of the AS-C proteins, is also associated with the CRC functioning. In this paper, we propose a mathematical model for the CRC functioning as a regulator of the amount of proneural AS-C proteins in the SOP cell taking into account their degradation. The modeling has demonstrated that a change in the amount of proneural proteins in the SOP cell is stepwise rather than strictly monotonic. This prediction can be tested experimentally.

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Section: Methodsmentioning

confidence: 99%

“…5 Functioning of the CRC provides expression of AS-C, the major element of the overall system for macrochaete morphogenesis. In the CRC, expression of the AS-C and, correspondingly, production of the proneural proteins are controlled via positive and negative regulations.…”

Section: Introductionmentioning

confidence: 99%

A model study of the morphogenesis ofD. melanogastermechanoreceptors: The central regulatory circuit

Golubyatnikov

Бухарина

Furman

2015

J. Bioinform. Comput. Biol.

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“…Whereas morphological description of the mechanoreceptors seems easier to be performed, analyzing the sense of touch from a genetic perspective proves to be more difficult. The reason for this is that even in simpler model organisms, like Drosophila melanogaster , mechanoreceptors’ development is regulated by a complicated gene network . Thus, understanding the molecular mechanism of touch in nocturnal and diurnal birds may be unrealistic at the current state of our knowledge.…”

Section: Genomic Changes Accompany Adaptation To Nocturnalitymentioning

confidence: 99%

Adaptation to nocturnality – learning from avian genomes

Duc

Schöneberg

2016

BioEssays

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The recent availability of multiple avian genomes has laid the foundation for a huge variety of comparative genomics analyses including scans for changes and signatures of selection that arose from adaptions to new ecological niches. Nocturnal adaptation in birds, unlike in mammals, is comparatively recent, a fact that makes birds good candidates for identifying early genetic changes that support adaptation to dim-light environments. In this review, we give examples of comparative genomics analyses that could shed light on mechanisms of adaptation to nocturnality. We present advantages and disadvantages of both "data-driven" and "hypothesis-driven" approaches that lead to the discovery of candidate genes and genetic changes promoting nocturnality. We anticipate that the accessibility of multiple genomes from the Genome 10K Project will allow a better understanding of evolutionary mechanisms and adaptation in general.

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“…в целом, позволила нам реконструировать три генных сети, связанных с тремя этапами этого процесса и отражающих иерархическую организацию молекулярно-генетической системы обеспечения морфогенеза щетиночного рисунка [1][2][3].…”

Section: Introductionunclassified

Mathematical and numerical models of the central regulatory circuit of the morphogenesis system of Drosophila

Бухарина¹,

Akinshin²,

Golubyatnikov³

et al. 2020

Sib. Zh. Ind. Mat.

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The results are presented of mathematical and computer simulation of the functioning of the central regulatory circuit (CRC) which is the system integrator of gene networks of morphogenesis of Drosophila mechanoreceptors. The main element of the CRC is represented by the complex of achaete-scute (AS-C) genes, the main genes of the mechanoreceptor morphogenesis. The content level of the proteins encoded by the AS-C genes is a determining factor for initiating the development of a mechanoreceptor. We carried out a comparative study of the CRC behavior under normal conditions and in the presence of mutational changes in the achaete-scute complex. The results of simulation are in good accord with the available biological data.

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The gene network determining development of Drosophila melanogaster mechanoreceptors

Cited by 11 publications

References 13 publications

A model study of the morphogenesis ofD. melanogastermechanoreceptors: The central regulatory circuit

A model study of the morphogenesis ofD. melanogastermechanoreceptors: The central regulatory circuit

Adaptation to nocturnality – learning from avian genomes

Mathematical and numerical models of the central regulatory circuit of the morphogenesis system of Drosophila

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