volume 87, issue 3, P351-355 2009
DOI: 10.1038/clpt.2009.218
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Abstract: Drug use in clinical practice often deviates from the carefully scripted use in controlled clinical trials or the evidence-based guidance in drug labels. The prescribers' judgments may result in a wider spectrum of disease being treated, including those in patients with more comorbidities. Prescribed doses, as well as patient compliance and adherence, may differ from the experience in the classical clinical trial setting. This may result in an unanticipated (and unfavorable) shift in the benefit-torisk ratio …

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