The GABAB receptor and recognition memory: possible modulation of its behavioral effects by the nitrergic system

Pitsikas, Nikolaos; Rigamonti, Antonello E.; Cella, Silvano G.; Müller, Eugenio E.

doi:10.1016/s0306-4522(03)00067-8

Cited by 61 publications

(38 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This conclusion is consistent with behavioral pharmacological studies, which suggest that NO can alter behavior in mice and rats by modulating 5-HT 1 receptor function (Chiavegatto and Nelson 2003;Pitsikas et al 2005). Lymnaea also possesses a 5-HT 1 -like receptor (Sugamori et al 1993) that is expressed in the buccal ganglia (Gerhardt 1996).…”

Section: Discussionsupporting

confidence: 82%

“…NO can also affect 5-HT re-uptake (Bryan-Lluka et al 2004) and appears to interact with selective 5-HT re-uptake inhibitors used in the treatment of depression (Harkin et al 2003(Harkin et al , 2004Inan et al 2004). Furthermore, behavioral studies have suggested that NO modulates 5-HT 1 receptor function (Chiavegatto and Nelson 2003;Pitsikas et al 2005).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modulation of Serotonergic Neurotransmission by Nitric Oxide

Straub

Grant²,

O’Shea³

et al. 2007

Journal of Neurophysiology

View full text Add to dashboard Cite

tric oxide (NO) and serotonin (5-HT) are two neurotransmitters with important roles in neuromodulation and synaptic plasticity. There is substantial evidence for a morphological and functional overlap between these two neurotransmitter systems, in particular the modulation of 5-HT function by NO. Here we demonstrate for the first time the modulation of an identified serotonergic synapse by NO using the synapse between the cerebral giant cell (CGC) and the B4 neuron within the feeding network of the pond snail Lymnaea stagnalis as a model system. Simultaneous electrophysiological recordings from the pre-and postsynaptic neurons show that blocking endogenous NO production in the intact nervous system significantly reduces the B4 response to CGC activity. The blocking effect is frequency dependent and is strongest at low CGC frequencies. Conversely, bath application of the NO donor DEA/NONOate significantly enhances the CGC-B4 synapse. The modulation of the CGC-B4 synapse is mediated by the soluble guanylate cyclase (sGC)/cGMP pathway as demonstrated by the effects of the sGC antagonist 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ). NO modulation of the CGC-B4 synapse can be mimicked in cell culture, where application of 5-HT puffs to isolated B4 neurons simulates synaptic 5-HT release. Bath application of diethylamine NONOate (DEA/NONOate) enhances the 5-HT induced response in the isolated B4 neuron. However, the cell culture experiment provided no evidence for endogenous NO production in either the CGC or B4 neuron suggesting that NO is produced by an alternative source. Thus we conclude that NO modulates the serotonergic CGC-B4 synapse by enhancing the postsynaptic 5-HT response.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Modulation of Serotonergic Neurotransmission by Nitric Oxide

Straub

Grant²,

O’Shea³

et al. 2007

Journal of Neurophysiology

View full text Add to dashboard Cite

show abstract

“…In this case, enhanced sensitivity of 5-HT 1A receptors, caused by early MDMA exposure, could be responsible for these long-term deficits in learning and memory. For example, just as performance on spatial memory and avoidance learning tasks is impaired by stimulating 5-HT 1A receptors (Bertrand et al, 2000;Bevilaqua et al, 1997;Lee et al, 1992;Pitsikas et al, 2005), it is possible that an MDMA-induced increase in the sensitivity of 5-HT 1A receptors also impairs memory performance.…”

Section: Discussionmentioning

confidence: 99%

Neonatal 3,4-methylenedioxymethamphetamine (MDMA) exposure alters neuronal protein kinase A activity, serotonin and dopamine content, and [35S]GTPγS binding in adult rats

et al. 2006

View full text Add to dashboard Cite

Recreational use of methylenedioxymethamphetamine (MDMA) has dramatically increased among juveniles and young adults of child-bearing age, and the potential for fetal exposure has increased. For this reason, it is surprising that comparatively few studies have assessed the long-term impact of early MDMA exposure on serotonin (5-HT) and dopamine (DA) neurotransmitter systems. The purpose of this study was to determine whether repeated exposure to MDMA during the preweanling period would cause long-term changes in 5-HT and DA functioning. Rats were treated with saline or 20 mg/kg MDMA (two injections per day) from postnatal day (PD) 11-20. At PD 90, rats were killed, and their dorsal striatum, prefrontal cortex, and hippocampus were removed. 5-HT and DA content, as well as their metabolites, were measured using HPLC. In addition, cAMP-dependent protein kinase A (PKA) activity and agonist-stimulated [ 35 S]GTPγS binding was assayed using tissue homogenates from each brain region. Results indicated that early MDMA exposure caused a decrease in PKA activity and 5-HT content in the prefrontal cortex and hippocampus while increasing the efficacy of 5-HT 1A receptors as measured by agonist-stimulated [ 35 S]GTPγS binding. Additionally, DA content was reduced in the dorsal striatum and prefrontal cortex. These data indicate that early MDMA exposure has long-term effects on the 5-HT and DA neurotransmitter systems that may be mediated, at least partially, by changes in 5-HT 1A receptor sensitivity.

show abstract

“…We chose a strain of rats with known age-related biological changes in the brain [4][5][6]12,25] and a delay period for the novel object recognition task based on studies in which there are age-related deficits in the novel object recognition task [19,26]. Surprisingly our results demonstrated that there was no difference in young and aged rats in the time spent exploring the novel object.…”

Section: Discussionmentioning

confidence: 87%

“…While it was surprising that there was no deficit, it was not unusual as the effects of age on novel object recognition have been equivocal in whether or not age-related differences have been observed [19][20][21][22][23]26,27]. The question then remains what could be contributing to these different results.…”

Section: Discussionmentioning

confidence: 99%

Novel object recognition is not affected by age despite age-related brain changes

Aktoprak¹,

Dinc²,

Günay³

et al. 2013

WJNS

View full text Add to dashboard Cite

Age-related memory impairments show a progressive decline across lifespan. Studies have demonstrated equivocal results in biological and behavioral outcomes of aging. Thus, in the present study we examined the novel object recognition task at a delay period that has been shown to be impaired in aged rats of two different strains. Moreover, we used a strain of rats, Fisher 344XBrown Norway, which have published age-related biological changes in the brain. Young (10 months old) and aged (28 months old) rats were tested on a standard novel object recognition task with a 50 minutes delay period. The data showed that young and aged rats in the strain we used performed equally well on the novel object recognition task and that both young and old rats demonstrated a righthanded side preference for the novel object. Our data suggested that novel object recognition is not impaired in aged rats although both young and old rats have a demonstrated side preference. Thus, it may be that genetic differences across strains contribute to the equivocal results in behavior, and genetic variance likely influences the course of cognitive aging.

show abstract

The GABAB receptor and recognition memory: possible modulation of its behavioral effects by the nitrergic system

Cited by 61 publications

References 45 publications

Modulation of Serotonergic Neurotransmission by Nitric Oxide

Modulation of Serotonergic Neurotransmission by Nitric Oxide

Neonatal 3,4-methylenedioxymethamphetamine (MDMA) exposure alters neuronal protein kinase A activity, serotonin and dopamine content, and [35S]GTPγS binding in adult rats

Novel object recognition is not affected by age despite age-related brain changes

Contact Info

Product

Resources

About