The G209A Mutation in the α-Synuclein Gene Is Not Detected in Familial Cases of Parkinson Disease in Non-Greek and/or Italian Populations

Abstract

The G209A mutation is rare in US patients with familial PD.

Analysis of the coding and the 5′ flanking regions of the α‐synuclein gene in patients with Parkinson's disease

“…However, a low possibility still exists that some sequence variants could have been missed. The lack of clearly pathogenic mutations in the α‐synuclein gene has also been reported in previous studies from other populations 16, 19–22. These results, together with the absence of association of the new 5′flanking region polymorphism found in this study, suggest that mutations in the α‐synuclein gene are a very rare cause of PD.…”

Analysis of the coding and the 5′ flanking regions of the α‐synuclein gene in patients with Parkinson's disease

“…However, a low possibility still exists that some sequence variants could have been missed. The lack of clearly pathogenic mutations in the α‐synuclein gene has also been reported in previous studies from other populations 16, 19–22. These results, together with the absence of association of the new 5′flanking region polymorphism found in this study, suggest that mutations in the α‐synuclein gene are a very rare cause of PD.…”

Genetic assessment of familial and early‐onset Parkinson's disease in a Greek population

“…This is the first mutation to have been associated with PD in one Italian and three unrelated Greek families originating from Northern Peloponnese . Later, a few more Greek families were reported to carry the mutation , whilst it has been very rarely detected in patients of non‐Greek origin . Therefore, SCNA‐A53T represents a rare cause of familial PD, basically confined to families originating from Greece and southern Italy where a common single founder may exist.…”

Molecular analysis of α-synuclein gene in Parkinson′s disease in North Karnataka, India

“…[19] Many studies conducted worldwide related to the pathogenicity of SNCA gene in PD reveal the lack of mutations. [20][21][22][23][24][25] India is known for high degree of inbreeding with its heterogynous population. This makes it necessary to screen a large number of patients perhaps within each group in order to get a true picture of contribution of SNCA gene mutation to PD.…”

Analysis of the coding and the 5′ flanking regions of the α‐synuclein gene in patients with Parkinson's disease

“…However, a low possibility still exists that some sequence variants could have been missed. The lack of clearly pathogenic mutations in the α‐synuclein gene has also been reported in previous studies from other populations 16, 19–22. These results, together with the absence of association of the new 5′flanking region polymorphism found in this study, suggest that mutations in the α‐synuclein gene are a very rare cause of PD.…”

Genetic assessment of familial and early‐onset Parkinson's disease in a Greek population

“…This is the first mutation to have been associated with PD in one Italian and three unrelated Greek families originating from Northern Peloponnese . Later, a few more Greek families were reported to carry the mutation , whilst it has been very rarely detected in patients of non‐Greek origin . Therefore, SCNA‐A53T represents a rare cause of familial PD, basically confined to families originating from Greece and southern Italy where a common single founder may exist.…”

Molecular analysis of α-synuclein gene in Parkinson′s disease in North Karnataka, India

“…[19] Many studies conducted worldwide related to the pathogenicity of SNCA gene in PD reveal the lack of mutations. [20][21][22][23][24][25] India is known for high degree of inbreeding with its heterogynous population. This makes it necessary to screen a large number of patients perhaps within each group in order to get a true picture of contribution of SNCA gene mutation to PD.…”

Analysis of the coding and the 5′ flanking regions of the α‐synuclein gene in patients with Parkinson's disease

“…However, a low possibility still exists that some sequence variants could have been missed. The lack of clearly pathogenic mutations in the α‐synuclein gene has also been reported in previous studies from other populations 16, 19–22. These results, together with the absence of association of the new 5′flanking region polymorphism found in this study, suggest that mutations in the α‐synuclein gene are a very rare cause of PD.…”

Genetic assessment of familial and early‐onset Parkinson's disease in a Greek population

“…This is the first mutation to have been associated with PD in one Italian and three unrelated Greek families originating from Northern Peloponnese . Later, a few more Greek families were reported to carry the mutation , whilst it has been very rarely detected in patients of non‐Greek origin . Therefore, SCNA‐A53T represents a rare cause of familial PD, basically confined to families originating from Greece and southern Italy where a common single founder may exist.…”

Molecular analysis of α-synuclein gene in Parkinson′s disease in North Karnataka, India

“…[19] Many studies conducted worldwide related to the pathogenicity of SNCA gene in PD reveal the lack of mutations. [20][21][22][23][24][25] India is known for high degree of inbreeding with its heterogynous population. This makes it necessary to screen a large number of patients perhaps within each group in order to get a true picture of contribution of SNCA gene mutation to PD.…”