The functional lumen imaging probe in gastrointestinal disorders: the past, present, and future

Abstract

The functional lumen imaging probe (FLIP) is a diagnostic tool that utilizes impedance planimetry to allow the assessment of luminal diameter and distensibility. It has been used primarily in esophageal diseases, in particular, in the assessment of achalasia, esophagogastric junction outflow obstruction, and eosinophilic esophagitis (EoE). The usage and publications have increased over the past decade and it is now an essential tool in the armamentarium of the esophagologist. Indications are emerging outside of the esophagus, in particular with regard to gastroparesis. Our paper will review the history of FLIP, optimal current usage, data for key esophageal disorders (including achalasia, reflux, and EoE), data for nonesophageal disorders, and our sense as to whether FLIP is ready for prime time, as well as gaps in evidence and suggestions for future research.

Short-term outcomes of different modalities of pyloromyotomy versus gastric electrical stimulation in the treatment of gastroparesis

“…[ 33 ] Even the functional lumen imaging probe still possesses certain technical obstacles to resolve, as well as having standardized normative parameters. [ 34 ] Secondly, it is challenging to estimate the clinical outcomes of refractory gastroparesis after a procedure when reporting bias exists due to different outcome definitions, assessments, and follow up periods. Nevertheless, we comprehensively evaluated the short-term outcomes of 3 different types of pyloromyotomy and GES in the treatment of gastroparesis using head-to-head comparisons.…”

Primary eosinophilic gastrointestinal disorders and allergy: Clinical and therapeutic implications

“…It is characterized by the presence of esophageal infiltration in both the proximal and distal esophagus. The disrupted function of the muscolaris mucosa layer, which can be shown by ultrasonography, results in symptoms of esophageal dysmotility 25 …”

“…The disrupted function of the muscolaris mucosa layer, which can be shown by ultrasonography, results in symptoms of esophageal dysmotility. 25 …”

“…The disrupted function of the muscolaris mucosa layer, which can be shown by ultrasonography, results in symptoms of esophageal dysmotility. 25 Most of the studies considering the relationship between EGID and asthma are focused on EoE, probably because EoE is the most frequent form of EGID, paralleling the epidemiologic surge of allergic diseases. 7,26 Several studies have shown that patients with EoE suffer from a significant burden of allergic comorbidities, such allergic rhinitis, asthma, atopic dermatitis, and IgE-mediated food-allergy.…”

EndoFLIP: una nueva tecnología

“…Entonces, la EndoFLIP (sonda de imagen endoluminal funcional) es un sistema que mide en tiempo real el índice de distensibilidad de la unión gastroesofágica (UGE-ID) y el peristaltismo esofágico secundario a través de planimetría de impedancia de alta resolución (3)(4)(5). La evaluación inicial de la planimetría de impedancia como prueba se realizó a finales de la década de 1980 y los primeros estudios se realizaron con los dispositivos en la década de los 1990 (6). A principios de la década de los 2000, varios grupos pioneros liderados por Mittal, Pandolfino y Shaker intentaron abordar varias preguntas sobre el uso de este dispositivo en la evaluación de la distensibilidad y la competencia del esfínter, y sus propiedades biomecánicas.…”