The frequency of factor V Leiden mutation, ACE gene polymorphism, serum ACE activity and response to ACE inhibitor and angiotensin II receptor antagonist drugs in Iranians type II diabetic patients with microalbuminuria

Shakiba, Ebrahim; Felehgari, Vahid; Rahimi, Mehrali; Rahimi, Ziba; Vaisi‐Raygani, Asad; Mozafari, Hadi; Yari, Kheirollah; Rahimi, Zohreh

doi:10.1016/j.clinbiochem.2011.08.104

Cited by 9 publications

(10 citation statements)

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“…31,32 The D allele and DD genotype have been reported to be associated with higher plasma ACE levels. 33,34 ACE is a key enzyme of RAAS which can convert inactive angiotensin I into a vasoactive and aldosteronestimulating peptide angiotensin II. 35,36 The elevated expression of ACE protein might be responsible for the elevation of plasma angiotensin II level.…”

Section: Discussionmentioning

confidence: 99%

Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis

Zhou

Qin

et al. 2011

J Renin Angiotensin Aldosterone Syst

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Background and objective: Angiotensin converting enzyme (ACE) gene contains either an insertion (I) allele or a deletion (D) allele forming three potential genotypes: II, ID and DD. The D allele or DD genotype has been reported to be associated with higher plasma ACE level. An assessment of the association between ACE I/D gene polymorphism and idiopathic nephrotic syndrome (INS) susceptibility in children is still controversial. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and the onset of INS. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases, and eligible investigations were synthesized using the meta-analysis method. Conclusions: D allele and DD homozygous might become significant genetic molecular markers for INS susceptibility in Asian children, but the association was not observed in Caucasians or Africans. However, the conclusion from our study cannot be sustained and more investigations on larger sample in different populations are required to further clarify the role of D allele or DD homozygous in the onset of INS in difference races.

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Section: Discussionmentioning

confidence: 99%

Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis

Zhou

Qin

et al. 2011

J Renin Angiotensin Aldosterone Syst

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“…Previously, we reported the frequency of ACE I/D polymorphism in T2DM patients with micro‐ and macro‐albuminuria and lack of significant association between diabetic nephropathy and ACE polymorphism 1,20 . In the present study we planned to determine whether the concomitant presence of both ACE I/D and eNOS G894T polymorphisms have an effect on the risk of DN in T2DM patients from Western Iran.…”

mentioning

confidence: 88%

Concomitant presence of endothelial nitric oxide 894T and angiotensin II‐converting enzyme D alleles are associated with diabetic nephropathy in a Kurdish population from Western Iran

Rahimi

Vaisi‐Raygani

Rahimi³

et al. 2012

Nephrology

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Our study indicates that the concomitant presence of both ACE D and eNOS T alleles tends to be associated with an elevation risk of macroalbuminuria compared with the presence of each polymorphism alone. This risk could be attributed to the increasing activity of ACE and angiotensin II level in the presence of D allele and decreasing NO production in the presence of T allele accelerating diabetic nephropathy.

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“…Polymerase Chain Reaction (PCR) was performed to determine the different genotypes of ACE I/D. The specific primers were: Fwd: 5'-CTG GAG ACC ACT CCC ATC CTT TCT -3'; and Rev:5'-GAT GTG GCC ATC ACA TTC GTC AGA T -3' [18]. Briefly, PCR was carried out using 20 pmol of each primer, 200 μMdNTPs, 1.5 mM MgCl 2 , 1U Taq DNA polymerase enzyme in a 10X PCR buffer and 300-500 ng genomic DNA in total volume of 25 μl.…”

Section: Dna Extraction and Genotyping For The Ace Insertion/ Deletion Polymorphismsmentioning

confidence: 99%

Association between Angiotensin Converting Enzyme Insertion/Deletion Polymorphism and Soluble Receptor of Advanced Glycation End Products in Type 2 Diabetic Patients with and without Microalbuminuria

Gaber¹

2014

J Mol Biomark Diagn

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Aims/Introduction: Studies on the association between a deletion variant of the angiotensin-converting enzyme (ACE) gene and diabetic microalbuminuria and its impact on AGE/RAGE system remain inconclusive. Therefore, we aimed to study the association between ACE I/D polymorphism and the circulating levels of sRAGE (soluble receptor for advanced glycation end-products (sRAGE), pentosidine and advanced oxidation protein products (AOPPs) in type 2 diabetic patients with and without microalbuminuria.Subjects and methods: ACE I/D polymorphism was analyzed using the amplified fragment length polymorphism Polymerase Chain Reaction method (AFLP). Circulating levels of sRAGE and pentosidine were assessed using enzyme linked immunosorbent assay, while AOPPs were assessed photometrically.Results: within the diabetic normoalbuminuric group, DD and DI ACE genotypes were associated with significantly higher levels of sRAGE, Pentosidine and AOPPs (3280 ± 155 pg/mL, 289 ± 65 ng/ml and 192 ± 4.9 μmol/l ) respectively than those with the II genotype (2985 ± 310 pg/mL, 231 ± 66 ng/ml and 169 ± 7.5 μmol/l respectively, p<0.05). Also the microalbuminuric group exhibited a significant association between DD and DI ACE genotypes and higher levels of sRAGE, Pentosidine and AOPPs (10.2 ± 2.5%, 4975 ± 256 pg/mL, 305 ± 24 ng/ml and 207 ± 5.4 μmol/l ) respectively than those with the II genotype (4566 ± 219 pg/mL, 277 ± 15 ng/ml and 199 ± 7.6 μmol/l respectively, p<0.05). Conclusions:Both ID and DD ACE genotypes might represent a risk factor for diabetic renal complications being associated with significantly higher levels of sRAGE, pentosidine and AOPPs.

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The frequency of factor V Leiden mutation, ACE gene polymorphism, serum ACE activity and response to ACE inhibitor and angiotensin II receptor antagonist drugs in Iranians type II diabetic patients with microalbuminuria

Cited by 9 publications

References 0 publications

Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis

Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis

Concomitant presence of endothelial nitric oxide 894T and angiotensin II‐converting enzyme D alleles are associated with diabetic nephropathy in a Kurdish population from Western Iran

Association between Angiotensin Converting Enzyme Insertion/Deletion Polymorphism and Soluble Receptor of Advanced Glycation End Products in Type 2 Diabetic Patients with and without Microalbuminuria

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