2010
DOI: 10.1590/s1516-84842010000100017
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The frequency of β-globin gene haplotypes, α-thalassemia and genetic polymorphisms of methylenetetrahydrofolate reductase, factor V Leiden and prothrombin genes in children with sickle cell disease in Rio de Janeiro, Brazil

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Cited by 6 publications
(3 citation statements)
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“…The high prevalence rates of the CAR (56.6%) and Benin (33.6%) haplotypes in Minas Gerais were similar to those observed in a previous study, and agrees with historical records that describe these African regions as the origin of the slave trade from Africa to Brazil. The slaves that arrived in Minas Gerais had diverse African origins; those coming from Rio de Janeiro were mainly from Angola and Congo, where the CAR (Bantu) haplotype predominates, and those coming from Bahia were mainly from the Bay of Benin, where the Benin haplotype is most common 42‐44 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The high prevalence rates of the CAR (56.6%) and Benin (33.6%) haplotypes in Minas Gerais were similar to those observed in a previous study, and agrees with historical records that describe these African regions as the origin of the slave trade from Africa to Brazil. The slaves that arrived in Minas Gerais had diverse African origins; those coming from Rio de Janeiro were mainly from Angola and Congo, where the CAR (Bantu) haplotype predominates, and those coming from Bahia were mainly from the Bay of Benin, where the Benin haplotype is most common 42‐44 …”
Section: Discussionmentioning
confidence: 99%
“…The slaves that arrived in Minas Gerais had diverse African origins; those coming from Rio de Janeiro were mainly from Angola and Congo, where the CAR (Bantu) haplotype predominates, and those coming from Bahia were mainly from the Bay of Benin, where the Benin haplotype is most common. [42][43][44] HSCT is the only curative treatment for SCD and was incorporated in the Brazilian National Health System (SUS) since 2015 (allogenic HSCT with related donor), but it is limited by donor availability. The possibility of using alternative stem-cell sources could increases the chance of finding a compatible donor.…”
Section: Discussionmentioning
confidence: 99%
“…It predominantly affects the Black population and presents clinical manifestations within the first years of life with repercussions on morbidity and mortality 1, 2. Despite technological and scientific advances to improve the prognosis of sickle cell disease, its management persists as a challenge for professional healthcare providers, since it involves complex aspects of diagnosis, treatment and prevention of complications 3, 4, 5…”
Section: Introductionmentioning
confidence: 99%