Biochemical Pharmacology volume 81, issue 6, P810-818 2011 DOI: 10.1016/j.bcp.2010.12.020 View full text
Lakshmi Ganesan, Emilio Margolles-Clark, Yun Song, Peter Buchwald

Abstract: Following our observation that erythrosine B (FD&C Red No. 3) is a relatively potent inhibitor of the TNF-R-TNFα and CD40-CD154 protein-protein interactions, we investigated whether this inhibitory activity extends to any other protein-protein interactions (PPI) as well as whether any other approved food colors possess such inhibitory activity. We found erythrosine, a poly-iodinated xanthene dye, to be a non-specific promiscuous inhibitor of a number of PPIs within the tumor necrosis factor superfamily (TNF-R-…

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