The flavonoid-rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin-induced glucose-intolerant rats

Dias, Teresa; Bronze, Maria Rosário; Houghton, Peter J.; Mota-Filipe, Hélder; Paulo, Alexandra

doi:10.1016/j.jep.2010.08.048

Cited by 88 publications

(79 citation statements)

References 26 publications

(46 reference statements)

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“…Since cinnamic acid derivatives have been reported to promote insulin secretion (Adisakwattana et al, 2008), the possibility that AFE affects insulin secretion is an interesting concept. There have been several studies on the hypoglycemic activity and antidiabetic effects of flowers and their constituents (Bhaskar et al, 2011;Dias et al, 2010;Nakamura et al, 2011); however, there have been no reports on these effects in a type 2 diabetes model. Although the influence of AFE on insulin secretion in normal mice was not elucidated in this study, plasma glucose levels were lowered in a dose-dependent manner with AFE in the ICR mice that had a normal insulin response.…”

Section: Kk-a Y Micementioning

confidence: 99%

Investigation of the Safety and Antihyperglycemic Effect of <i>Apios americana</i> Flower Intake as a Food Material in Normal and Diabetic Mice

Kawamura

Miura

Kawakishi³

et al. 2015

FSTR

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Section: Kk-a Y Micementioning

confidence: 99%

Investigation of the Safety and Antihyperglycemic Effect of <i>Apios americana</i> Flower Intake as a Food Material in Normal and Diabetic Mice

Kawamura

Miura

Kawakishi³

et al. 2015

FSTR

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“…Our previous study indicated that the flavonoids extracted from CT show anti-hyperlipidemic effects, particularly in lowering triglycerides, reducing lipid deposition, and protecting liver function in an animal model [9]. Some pharmacological studies have also reported that CT is rich in flavonoids and can adjust glucose metabolism, promote blood circulation, and reduce cardiovascular disease risk [10,11]. Thus, a retrospective analysis was performed in patients with hyperlipidemia in this study, and we validated a protective role of CT in patients with hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

Coreopsis Tinctoria Modulates Lipid Metabolism by Decreasing Low-Density Lipoprotein and Improving Gut Microbiota

Ren

Liu

et al. 2018

Cell Physiol Biochem

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Background/Aims: The prevalence of hyperlipidemia is increasing rapidly. The role of Coreopsis tinctoria (CT) in amending lipid metabolism in hyperlipidemia patients has not been reported. This study aims to evaluate the role of CT in altering lipid metabolism in hyperlipidemia patients and to explore the possible mechanisms mediated by gut microbiota in hyperlipidemia mice models. Methods: A retrospective analysis in 40 hyperlipidemia patients was conducted, in which 20 patients took fenofibrate and another 20 patients normatively drank water with CT. Hyperlipidemia mice models were also established. Blood biochemical tests were performed using an automatic biochemical analyzer. Liver histopathology was observed by hematoxylin and eosin staining. Ileocecal samples were collected from mice, and bacterial DNA was extracted and sequenced by MiSeq sequencing. Bacterial composition and differences were analyzed. Results: In hyperlipidemia patients, CT was associated with decreased triglyceride and low-density lipoprotein (LDL) levels without liver injury. The experimental hyperlipidemia model also verified a similar result. Gut microbial richness and diversity were significantly decreased in hyperlipidemic mice, but increased after CT treatment. Bacterial communities were significantly differentiated between normal controls and hyperlipidemic mice. CT administration improved gut microbiota composition to an approximately normal status. Meanwhile, CT administration attenuated bacterial alterations at the class, order, family, and genus levels in hyperlipidemic mice. Importantly, the genera Barnesiella, Lactobacillus, and Helicobacter achieved high discriminatory power in hyperlipidemic mice relative to normal controls. Conclusions: CT can modulate blood lipid metabolism with improvement of liver function by decreasing LDL and improving gut microbiota compositions. These findings may provide novel therapeutic strategies for patients with hyperlipidemia.

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“…have a significant amounts of bioactive components. 6,10,11 C. tinctoria is an annual forb widespread in Canada, Northeast Mexico, much of the United States, especially the Great Plains and Southern states, and is often called "calliopsis" by the native residents.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Total Flavonoids Extraction from Coreopsis tinctoria Nutt. by Response Surface Methodology

Liu¹

2014

Kem. Ind.

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Response surface methodology (RSM) was applied to predict optimum conditions for extraction of flavonoid from Coreopsis tinctoria Nutt. A central composite design (CCD) was used to monitor the effect of extraction temperature, extraction time, and water-to-material ratio on yield of total flavonoids. The optimal extraction conditions were obtained as water-to-material ratio of 55 ml g −1 , extraction temperature of 80 °C and extraction time of 70 minutes. Under these conditions, the average total flavonoids yield, according to the mass of raw material, was 9.0 ± 0.6 %, which corresponds to the predicted value of 8.9 %. Thus, the extraction method was applied successfully to extract total flavonoids from C. tinctoria.

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The flavonoid-rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin-induced glucose-intolerant rats

Cited by 88 publications

References 26 publications

Investigation of the Safety and Antihyperglycemic Effect of <i>Apios americana</i> Flower Intake as a Food Material in Normal and Diabetic Mice

Investigation of the Safety and Antihyperglycemic Effect of <i>Apios americana</i> Flower Intake as a Food Material in Normal and Diabetic Mice

Coreopsis Tinctoria Modulates Lipid Metabolism by Decreasing Low-Density Lipoprotein and Improving Gut Microbiota

Optimization of Total Flavonoids Extraction from Coreopsis tinctoria Nutt. by Response Surface Methodology

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