The first report of human meningitis and pyogenic ventriculitis caused by  Streptococcus suis : A case report

Yanase, Tomonobu; Morii, Daiichi; Kamio, Satoshi; Nishimura, Ayako; Fukao, Eri; Inose, Yuri; Honma, Yutaka; Kitahara, Nobuo; Yokozawa, Takayuki; Chang, Bin; Oda, Toshimi

doi:10.1016/j.jiac.2018.01.009

Cited by 23 publications

(19 citation statements)

References 21 publications

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“…Of note, a total of 240 human cases with 53 deaths were recorded in China during two large outbreaks of S. suis 2 infection, which occurred in 1998 and 2005 [16,17]. In recent years, sporadic human cases of S. suis infection have been frequently reported worldwide [18][19][20][21][22], indicating that S. suis is a persistent threat to public health.…”

Section: Introductionmentioning

confidence: 99%

PmtA functions as a ferrous iron and cobalt efflux pump in Streptococcus suis

Zheng

Jia

Gao

et al. 2019

Emerging Microbes & Infections

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Transition metals are nutrients essential for life. However, an excess of metals can be toxic to cells, and host-imposed metal toxicity is an important mechanism for controlling bacterial infection. Accordingly, bacteria have evolved metal efflux systems to maintain metal homeostasis. Here, we established that PmtA functions as a ferrous iron [Fe(II)] and cobalt [Co(II)] efflux pump in Streptococcus suis, an emerging zoonotic pathogen responsible for severe infections in both humans and pigs. pmtA expression is induced by Fe(II), Co(II), and nickel [Ni(II)], whereas PmtA protects S. suis against Fe(II) and ferric iron [Fe(III)]-induced bactericidal effect, as well as Co(II) and zinc [Zn(II)]-induced bacteriostatic effect. In the presence of elevated concentrations of Fe(II) and Co(II), ΔpmtA accumulates high levels of intracellular iron and cobalt, respectively. ΔpmtA is also more sensitive to streptonigrin, a Fe(II)-activated antibiotic. Furthermore, growth defects of ΔpmtA under Fe(II) or Co(II) excess conditions can be alleviated by manganese [Mn(II)] supplementation. Finally, PmtA plays a role in tolerance to H 2 O 2-induced oxidative stress, yet is not involved in the virulence of S. suis in mice. Together, these data demonstrate that S. suis PmtA acts as a Fe(II) and Co(II) efflux pump, and contributes to oxidative stress resistance.

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Section: Introductionmentioning

confidence: 99%

PmtA functions as a ferrous iron and cobalt efflux pump in Streptococcus suis

Zheng

Jia

Gao

et al. 2019

Emerging Microbes & Infections

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“…Two fatal cases of PV complicating from infective endocarditis occurred in patients who suffered from infection of coagulase-negative Staphylococci or Aggregatibacter aphrophilus , a gramme-negative organism [6, 7]. Streptococci infection associated with PV is rare, but Streptococcus acidominimus or Streptococcus suis infections have been recently reported [9, 10].…”

Section: Discussionmentioning

confidence: 99%

Life-threatening pyogenic ventriculitis, complicating endocarditis, presenting as sudden hearing loss

Ito¹,

Koiwa²,

Watanabe³

et al. 2019

Oxford Medical Case Reports

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Approximately 70% of sudden sensorineural hearing loss (SSNHL) cases are idiopathic, but SSNHL may occasionally be related to fatality. Here, we report the case of a 54-year-old Asian female who complained of hearing loss as a primary symptom and was diagnosed with pyogenic ventriculitis (PV) derived from Streptococcus agalactiae endocarditis. Both PV and S. agalactiae endocarditis are rare and very severe infections with a high mortality rate. Rapid intensive treatment and surgery were required for successful clinical outcomes.

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“…Swine streptococcosis is a widespread infectious disease of zoonosis. Its high fatality rate leads to substantial economic losses in pig farms [1,2]. At present, the main problem of the treatment of swine streptococcus is resistance to antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol

Yuan

Liu

et al. 2020

Molecules

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The formation of bacterial biofilms has increased the resistance of bacteria to various environmental factors and is tightly associated with many persistent and chronic bacterial infections. Herein we design a strategy conjugating florfenicol, an antibiotic commonly used in the treatment of streptococcus, with the antimicrobial biomaterial, chitosan oligosaccharides. The results demonstrated that the florfenicol-COS conjugate (F-COS) efficiently eradicated the mature Streptococcus hyovaginalis biofilm, apparently inhibiting drug resistance to florfenicol. A quantity of 250 μg/mL F-COS showed effective inhibitory activity against planktonic cells and biofilm of the bacteria, and a 4-fold improvement of the F-COS compared to unmodified florfenicol was observed. Furthermore, the conjugate showed a broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It suggested that F-COS might have a potential for application in the treatment of biofilm-related infections.

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The first report of human meningitis and pyogenic ventriculitis caused by Streptococcus suis : A case report

Cited by 23 publications

References 21 publications

PmtA functions as a ferrous iron and cobalt efflux pump in Streptococcus suis

PmtA functions as a ferrous iron and cobalt efflux pump in Streptococcus suis

Life-threatening pyogenic ventriculitis, complicating endocarditis, presenting as sudden hearing loss

Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol

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