The First Effort for the Preparation of Amidoalkyl Naphthoquinone Skeleton Based on Solvent-Free Multicomponent Reaction

p-Toluenesulfonic acid-promoted organic transformations for the generation of molecular complexity

“…46 Consequently, a hybrid molecular structure containing chromene and other biologically active heterocycles may lead to the development of molecules of biological and pharmacological importance. In view of the significance of chromene annelated heterocycles, many )-dione and naphthalen-2-ol to produce a series of benzo [5,6]chromeno [3,2-c]quinolone derivatives in aqueous ethanol medium (Scheme 32). 47 A high yield of products (up to 92%) was isolated within 1-2 hours under reflux conditions.…”

“…4.3.6 11H-Benzo[a]benzo [6,7]chromeno[2,3-c]phenazine-11,16(17H)-dione. The group of Mohebat 55 described an attractive approach to the synthesis of 11H-benzo[a]benzo [6,7]chromeno[2,3-c]phenazine-11,16(17H)-dione from a four-component coupling reaction between 2-hydroxynaphthalene-1,4dione, o-phenylenediamine, aromatic aldehydes using p-TSA (20 mol%) in PEG-400 (Scheme 37). This chromatographic-free domino protocol worked proficiently with different aromatic aldehydes with impressive yields of the desired products within 3 h in a single operation.…”

Solvent free synthesis of amidoalkyl derivatives under green and convenient conditions

“…Quinones are one of the important biological structures in drug and natural products. Naphthoquinones, a category of quinones, are significant due to their properties like anticancer, antimalria, antiallerdic, and antibacterial [5]. So, new methods for the preparation of these compounds can be applicable in organic and pharmaceutical syntheses.…”

“…Amido alkyl derivatives have been synthesis with different homogeneous and heterogeneous catalysts like acidic catalysts [5,11–30], magnetic catalysts [31–33], ionic liquid [34–36], and metallic nanoparticles [37–41]. Some of them have disadvantages like long reaction times, low product yields, using of hazardous solvents, synthesis of catalysts in several stages, and use of expensive materials to the synthesis of catalysts.…”

“…It should be noted that amidomethyl β-naphtholes could be converted to important biological and pharmacological derivatives of by the hydrolysis reaction of amide. Amido alkyl derivatives have been synthesis with different homogeneous and heterogeneous catalysts like acidic catalysts [5,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], magnetic catalysts [31][32][33], ionic liquid [34][35][36], and metallic nanoparticles [37][38][39][40][41]. Some of them have disadvantages like long reaction times, low product yields, using of hazardous solvents, synthesis of catalysts in several stages, and use of expensive materials to the synthesis of catalysts.…”