The first dominant co-circulation of both dengue and chikungunya viruses during the post-monsoon period of 2010 in Delhi, India

Singh, Priyanka; Mittal, Veena; Rizvi, Abbas; Chhabra, Mala; Sharma, Pankaj; Rawat, Devendra Singh; Bhattacharya, Dipesh; Ls, Chauhan; Rai, Arvind

doi:10.1017/s0950268811001671

Cited by 51 publications

(33 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Few cases were also reported from Haryana and Uttar Pradesh [18,35]. With the view to establish identity of circulating genotype(s) in North India, we kept looking at the emerging trend of CHIKV since 2006, which caused an outbreak of CHIKV during post monsoon period of 2010 in Delhi [25].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India

Singh

Mittal

Rizvi

et al. 2012

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Re-emergence of chikungunya virus in South India after a gap of 32 years in 2006 affected over a million people in the Indian subcontinent. We kept a close vigil over the emerging trend of this virus between 2006-2010 with a view to establish the identity of the circulating genotype(s) and to determine the route of virus transmission in different parts of India. Methodology: Nucleotide sequencing of the E1 gene region from 36 strains of chikungunya virus from three states in northern India was performed for this present study. Forty-four previously reported E1 sequences, retrieved from the global genome data base were used for making a phylogenetic tree.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The morbidity and disability caused due to chikungunya is enormous. [18,25]. The present study was designed to determine the circulating genotype(s) of CHIKV in three northern Indian states, Delhi, Haryana, and Uttar Pradesh (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India

Singh

Mittal

Rizvi

et al. 2012

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…More recently, several outbreaks of dengue fever have been observed in Nepal [3], and these viruses were found to be genetically similar to those of strains isolated in India [4]. Co-circulation of both dengue virus (DENV) and CHIKV have been reported at regular intervals in India over the last few years [5]. The Ae.…”

Section: Introductionmentioning

confidence: 99%

First report of Chikungunya virus infection in Nepal

Pun

Bastola

Shah

2014

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…However, in the following years a downward shift in predominance of DENV-2 was recorded. The outbreaks occurred in 2006 and 2010 were predominated by DENV-3 and DENV-1 respectively [4,5]. Nearly after a decade, DENV-2 reemerged as predominant serotype during the outbreak in 2013 [6].…”

mentioning

confidence: 99%

“…Vigilance over the years recorded its continued circulation in the following years [2,8]. However, with emergence of DENV-3 in 2003, a downward shift in predominance of DENV-2 occurred, and its spread narrowed to sporadic cases [3][4][5]14]. After being persistent at low key for nearly a decade, it emerged as predominant serotype in 2013 outbreak [6].…”

mentioning

confidence: 99%

Molecular epidemiology and evolutionary analysis of dengue virus type 2, circulating in Delhi, India

et al. 2016

View full text Add to dashboard Cite

Dengue virus type 2 (DENV-2) has been associated with severe dengue outbreaks in many countries including India. Its predominance was recorded nearly after a decade in the capital city, Delhi in 2013. The present study characterizes DENV-2 circulated during 2013-2014. Analysis based on envelope (E) gene showed the presence of two clades (I and II) of DENV-2, within the Cosmopolitan genotype. Analysis of time of most recent common ancestor revealed the existence of clade I for more than a decade (95 % HPD 13-16 years) however, clade II showed comparatively recent emergence (95 % HPD 5-13 years). Presence of different clades is of high significance as this may result in increased virus transmission and major outbreaks. Further, the presence of a unique amino acid substitution, Q325H was also observed in an isolate; 14/D2/Del/2013 (KT717981). This substitution falls in immune epitope (epitope id: 150268) and may have important role in host immune response.Keywords Dengue Á Molecular epidemiology Á Envelope Á Evolutionary analysis Dengue fever is a mosquito borne infection caused by four antigenically-related serotypes of dengue virus (DENV-1, 2, 3 and 4). During the past decades dengue fever (DF) emerged as a major public health problem of global scale. Nearly 40 % of the world population is living at the risk of dengue infection. According to World Health Organization (available at http://www.searo.who.int/entity/vector_borne _tropical_diseases/data/data_factsheet/en/) it is the major cause of illness and deaths in tropical and subtropical regions, where Aedes mosquito population is high during rainy season. Dengue virus (DENV) belongs to the family Flaviviridae (genus; Flavivirus). Its genome consists of single stranded, positive sense RNA with approximately 11,000 nucleotides. A single open reading frame consists of three structural (capsid; C, premembrane/membrane; prM/ M and envelope; E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) flanked by nontranslated regions (5 0 UTR and 3 0 UTR) [1].Dengue is endemic in several parts of India. Many outbreaks have been reported from different parts of the country. During last two decades, Delhi, the national capital has emerged as one of the ''badly hit'' city by dengue. The city witnessed its first major dengue hemorrhagic fever (DHF) outbreak in 1996 [2]. Dengue virus type 2 (DENV-2) was confirmed as main etiological agent for this outbreak. During another outbreak in 2003, co-circulation of DENV-2 and DENV-3 was observed [3]. However, in the following years a downward shift in predominance of DENV-2 was recorded. The outbreaks occurred in 2006 and 2010 were predominated by DENV-3 and DENV-1 respectively [4,5]. Nearly after a decade, DENV-2 reemerged as predominant serotype during the outbreak in 2013 [6]. The emergence of DENV-2 is an alarming signal for public health, as this serotype has been associated with major DF and DHF outbreaks [2,[6][7][8]. Based on genomic Electronic supplementary material The online version of this a...

show abstract

The first dominant co-circulation of both dengue and chikungunya viruses during the post-monsoon period of 2010 in Delhi, India

Cited by 51 publications

References 12 publications

Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India

Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India

First report of Chikungunya virus infection in Nepal

Molecular epidemiology and evolutionary analysis of dengue virus type 2, circulating in Delhi, India

Contact Info

Product

Resources

About