The first comprehensive genomic characterization of rectal squamous cell carcinoma

Astaras, Christoforos; Vito, Claudio De; Chaskar, Prasad; Bornand, Aurélie; Khanfir, K.; Sciarra, Amedeo; Letovanec, Igor; Corrò, Claudia; Dietrich, Pierre‐Yves; Tsantoulis, Petros; Koessler, Thibaud

doi:10.1007/s00535-022-01937-w

Cited by 5 publications

(2 citation statements)

References 46 publications

(51 reference statements)

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“…Compared to the more common rAC, rSCC has a worse prognosis ( 5 , 6 ). rSCC and anal SCC (aSCC) have similar molecular features and are quite different from rAC ( 7 ). The pathogenesis of rSCC is currently unclear and may be related to smoking, previous exposure to radiation, chronic proctitis, squamous metaplasia, human immunodeficiency virus (HIV) infection, and human papillomavirus (HPV) infection ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Treatment paradigm and prognostic factor analyses of rectal squamous cell carcinoma

Zhang

et al. 2023

Front. Oncol.

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BackgroundRectal squamous cell carcinoma (rSCC) is a rare pathological subtype of rectal cancer. There is no consensus on the treatment paradigm for patients with rSCC. This study aimed to provide a paradigm for clinical treatment and develop a prognostic nomogram.MethodsPatients diagnosed with rSCC between 2010 and 2019 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. According to the TNM staging system, Kaplan−Meier (K-M) survival analysis was used to identify the survival benefits of different treatments in patients with rSCC. The Cox regression method was used to identify independent prognostic risk factors. Nomograms were evaluated by Harrell’s concordance index (C-index), calibration curves, decision curve analysis (DCA) and K-M curves.ResultsData for 463 patients with rSCC were extracted from the SEER database. Survival analysis showed that there was no significant difference in median cancer-specific survival (CSS) among patients with TNM stage 1 rSCC treated with radiotherapy (RT), chemoradiotherapy (CRT) or surgery (P = 0.285). In TNM stage 2 patients, there was a significant difference in median CSS among those treated with surgery (49.5 months), RT (24 months), and CRT (63 months) (P = 0.003). In TNM stage 3 patients, there was a significant difference in median CSS among those treated with CRT (58 months), CRT plus surgery (56 months) and no treatment (9.5 months) (P < 0.001). In TNM stage 4 patients, there was no significant difference in median CSS among those treated with CRT, chemotherapy (CT), CRT plus surgery and no treatment (P = 0.122). Cox regression analysis showed that age, marital status, T stage, N stage, M stage, PNI, tumor size, RT, CT, and surgery were independent risk factors for CSS. The 1-, 3-, and 5-year C-indexes were 0.877, 0.781, and 0.767, respectively. The calibration curve showed that the model had excellent calibration. The DCA curve showed that the model had excellent clinical application value.ConclusionRT or surgery is recommended for patients with stage 1 rSCC, and CRT is recommended for patients with stage 2, and stage 3 rSCC. Age, marital status, T stage, N stage, M stage, PNI, tumor size, RT, CT, and surgery are independent risk factors for CSS in patients with rSCC. The model based on the above independent risk factors has excellent prediction efficiency.

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Section: Introductionmentioning

confidence: 99%

Treatment paradigm and prognostic factor analyses of rectal squamous cell carcinoma

Zhang

et al. 2023

Front. Oncol.

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“…(5,6) The molecular expression of rSCC is similar to that of anal SCC (aSCC) and is quite different from that of rAC. (7) The pathogenesis of rSCC is not well understood and may be related to smoking, previous radiation exposure, chronic rectal in ammation, intestinal infection due to squamous metaplasia, HIV infection, HPV infection, or malignant transformation of persistent ectopic embryonic nests of ectodermal cells. (3) Since the rst discovery of rSCC in 1933, the number of reported rSCC has been so rare that some researchers have questioned whether this malignancy really exists.…”

Section: Introductionmentioning

confidence: 99%

Treatment paradigm and prognostic factor analysis of rectal squamous cell carcinoma- a retrospective study

Zhang

2023

Preprint

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Background：Rectal squamous cell carcinoma（rSCC）is a rare pathological type of rectal malignant tumors. There is no consensus on the treatment paradigm of patients with rSCC. This study aims to provide a paradigm for clinical treatment via analyzing the efficacy of different treatment regimens for patients with different TNM stages. Methods：Patients diagnosed with rSCC between 2010 and 2019 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. According to the TNM staging system, Kaplan-Meier（K-M）survival analysis was used to identify the survival benefits of patients with rSCC in different treatment groups. The Cox regression method was used to identify independent prognostic risk factors. Nomograms were evaluated by Harrell's concordance index, calibration curves, DCA and K-M curve. Results：463 patients with rSCC were extracted from the SEER database. Survival analysis showed that there was no significant difference in cancer specific survival (CSS) among radiotherapy（RT）, chemoradiotherapy（CRT）and surgeryin Stage 1 (P = 0.249). In TNM Stage 2, there was significant difference in CSS among surgery, RT, and CRT (P = 0.003). In TNM Stage 3, there was significant difference in CSS between CRT, no treatment and CRT plus surgery (P < 0.001). In TNM Stage 4, there was significant difference in CSS between CRT, no treatment and CT (P = 0.041). COX regression analysis showed that Age, Marital status, N, M, CEA, PIN, Size, RT, CT, and surgery were the independent risk factors. The 1-, 3-, and 5-year C-index was 0.869,0.777,0.759, respectively. The calibration curve showed that the model had excellent calibration. The DCA curve showed that the model had excellent clinical application value. Conclusion：RT or surgery is recommended for patients with rSCC at Stage 1, and CRT is recommended for patients with rSCCat Stage 2, Stage 3, and Stage 4. Age, marital status, N, M, PIN, size, RT, CT and surgery are independent risk factors for CSS in patients with rSCC. The prediction model composed of the above independent risk factors has excellent prediction efficiency.

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Plattenepithelkarzinom des Rektums

Holmer

2023

coloproctology

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The first comprehensive genomic characterization of rectal squamous cell carcinoma

Cited by 5 publications

References 46 publications

Treatment paradigm and prognostic factor analyses of rectal squamous cell carcinoma

Treatment paradigm and prognostic factor analyses of rectal squamous cell carcinoma

Treatment paradigm and prognostic factor analysis of rectal squamous cell carcinoma- a retrospective study

Plattenepithelkarzinom des Rektums

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