The fat regulator neuropeptide Y and caloric restriction

Park, Seongjoon; Mori, Ryoichi; Shimokawa, Isao

doi:10.18632/aging.101338

Cited by 3 publications

(4 citation statements)

References 7 publications

(7 reference statements)

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“…12,17 The role of neuropeptide Y includes regulating lipid metabolic homeostasis and survival via lipolysis and thermogenesis control pathways in a negative balance. 12,13,22 Neuropeptide Y is an appetite stimulator that increases fat collection through insulin and corticosteroid secretion, increases hepatic glucose utilization, reduces muscle glucose, increases glucose utilization by white fat tissue, activates brown fat tissue metabolism, decreases sympathetic activity, increases parasympathetic activity, and decreases thermogenesis 2,3,14,23 . Neurons containing neuropeptide Y become active during negative energy balance conditions such as hunger, dietary restrictions, breastfeeding, physical exercise, and uncontrolled diabetes 4,24,25 .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Neuropeptide Y is a key orexigenic neuropeptide that regulates adiposity by reducing energy storage and utilization [12][13][14] . Fasting conditions or low caloric intake stimulate neuropeptide Y expression, which increases appetite 12,13 . Neuropeptides are expressed mostly in the hypothalamus and in peripheral tissues such as white fat tissue and bone cells, which indicates that there are several other physiological functions apart from maintaining energy balance 12,15,16 .…”

Section: Introductionmentioning

confidence: 99%

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Sex Differences in Neuropeptide Y Serum, But Not in Fat Intake and Body Mass Index

Sari

Ichwan

Masyithah

et al. 2020

Preprint

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Background: One’s appetite has a role in controlling food intake and maintaining energy balance, but its effect on body metabolism related to obesity is still questionable. The purpose of this study was to determine the levels of neuropeptide Y in healthy people and to see differences in gender and anthropometric parameters. The hypothesis of this study was that there would be differences in neuropeptide Y levels in groups with gender and anthropometric parameter differences. Methods: This study was a cross-sectional study involving 62 study subjects, male and female, who did not have chronic diseases or metabolic disorders. This research was conducted from April to September 2020. The parameters examined in this study were neuropeptide Y levels and anthropometric parameters. The statistical analysis performed was the Mann-Whitney test to see the differences between groups. Results: The mean age of the research subjects was 40.48 ± 10.85 years, with the same ethnic distribution. The distribution of men and women was more women than men. Based on anthropometric examination, it was found that obesity nutritional status was more common in the female group than in the male group; however, serum neuropeptide Y levels were found to be significantly different between male and female groups (male group was higher). Conclusions: The study found significant differences in serum neuropeptide Y levels in male and female groups.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sex Differences in Neuropeptide Y Serum, But Not in Fat Intake and Body Mass Index

Sari

Ichwan

Masyithah

et al. 2020

Preprint

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“…Figure 1 b demonstrates that alternations in hypothalamic mediators inhibit HPO axis under CR. Initially, a series of rodent experiments discovered that CR activates AgRP neurons [ 11 ] and increases NPY mRNA level [ 37 ]. Also, CR decreases the expression of POMC [ 2 ] and CART [ 18 ].…”

Section: The Roles Of Cr In Hpo Axismentioning

confidence: 99%

Caloric restriction in female reproduction: is it beneficial or detrimental?

Sun

Shen

Liu

et al. 2021

Reprod Biol Endocrinol

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Caloric restriction (CR), an energy-restricted intervention with undernutrition instead of malnutrition, is widely known to prolong lifespan and protect against the age-related deteriorations. Recently it is found that CR significantly affects female reproduction via hypothalamic (corticotropin releasing hormone, neuropeptide Y, agouti-related peptide) and peripheral (leptin, ghrelin, insulin, insulin-like growth factor) mediators, which can regulate the energy homeostasis. Although CR reduces the fertility in female mammals, it exerts positive effects like preserving reproductive capacity. In this review, we aim to discuss the comprehensive effects of CR on the central hypothalamus-pituitary-gonad axis and peripheral ovary and uterus. In addition, we emphasize the influence of CR during pregnancy and highlight the relationship between CR and reproductive-associated diseases. Fully understanding and analyzing the effects of CR on the female reproduction could provide better strategies for the management and prevention of female reproductive dysfunctions.

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The fat regulator neuropeptide Y and caloric restriction

Cited by 3 publications

References 7 publications

Sex Differences in Neuropeptide Y Serum, But Not in Fat Intake and Body Mass Index

Sex Differences in Neuropeptide Y Serum, But Not in Fat Intake and Body Mass Index

Caloric restriction in female reproduction: is it beneficial or detrimental?

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