The Fat Overload Syndrome

Abstract

\s=b\A 10-month-old infant with hypoplasia of the intestinal mucosa had the fat over-From the

Manual plasma exchange to treat an accidental overdose of intravenous lipid emulsion in a dog with baclofen toxicosis

“…17 Both of these adverse effects were suspected in the dog described in the present report, because the serum was red, pigmenturia was detected, and the estimated platelet count decreased from 250,000 platelets/µL to 120,000 platelets/µL. In addition to thrombocytopenia, ILE overdose is associated with spontaneous coagulopathy 18 that may or may not be associated with prolonged clotting times and hypofibrinogenemia. In this dog, thromboelastography showed a low K time, α-angle, and maximum amplitude, consistent with hypofibrinogenemia and platelet dysfunction.…”

Rapid Infusion of Fish Oil–Based Emulsion in Infants Does Not Appear to be Associated With Fat Overload Syndrome

“…In another case report, a 10‐month‐old infant developed fat overload syndrome while receiving a soybean‐based intravenous fat emulsion at a dosage of 5 g/kg/d of fat for 5 weeks. The patient exhibited symptoms such as fever, jaundice, and bruising 20 . Elevations in serum transaminases, hyperbilirubinemia, and coagulopathies were also reported.…”

Brain Autopsy Findings in a Patient Who Received Lipid Emulsion Therapy for Suspected Drug Intoxication

“…A syndrome termed “fat overload syndrome” has been reported in cases with excessive accumulation of serum lipid 10,14,15 and is characterized with a sudden development of intolerance to the therapy, sudden elevation of serum lipid levels, fever, hepatosplenomegaly, hepatic dysfunction, coagulation problems, and end-organ failure. In particular, the coagulopathy has been the subject of several reports 10,16–18 .…”