The Farnesoid X Receptor Regulates Adipocyte Differentiation and Function by Promoting Peroxisome Proliferator-activated Receptor-γ and Interfering with the Wnt/β-Catenin Pathways

Abdelkarim, Mouaadh; Caron, Sandrine; Duhem, Christian; Prawitt, Janne; Dumont, Julie; Lucas, Anthony; Bouchaert, Emmanuel; Briand, Olivier; Brozek, John; Kuipers, Folkert; Fiévet, Catherine; Cariou, Bertrand

doi:10.1074/jbc.m110.166231

Cited by 85 publications

(72 citation statements)

References 43 publications

(45 reference statements)

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“…FXR plays a role in maintaining adipocyte differentiation and function ( 29,85,86 ) ( 96 ) and natural (oleanolic acid) ( 97 ) TGR5, but not with FXR agonists ( 98 ). Thus, TGR5 agonists might promote energy expenditure.…”

Section: Fxr and Glucose Metabolismmentioning

confidence: 99%

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

Porez

Prawitt²,

Gross³

et al. 2012

Journal of Lipid Research

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252

173

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Section: Fxr and Glucose Metabolismmentioning

confidence: 99%

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

Porez

Prawitt²,

Gross³

et al. 2012

Journal of Lipid Research

Self Cite

252

173

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“…In addition, FXR agonists also improved insulin resistance in the visceral preadipocytes of obese mice and rats [49,54] . FXR promotes adipocyte differentiation via the upregulation of PPARγ and interrupts the Wnt/ beta-catenin pathways [55,56] . In other words, FXR also plays an important role in the regulation of adipogenesis and insulin signaling.…”

Section: Fxr In Hepatic Glucose Metabolismmentioning

confidence: 99%

Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis

Jiao¹,

Lu²,

Li³

2014

Acta Pharmacol Sin

155

127

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Non-alcoholic fatty liver disease (NAFLD) is characterized by the aberrant accumulation of triglycerides in hepatocytes in the absence of significant alcohol consumption, viral infection or other specific causes of liver disease. NAFLD has become a burgeoning health problem both worldwide and in China, but its pathogenesis remains poorly understood. Farnesoid X receptor (FXR), a member of the nuclear receptor (NR) superfamily, has been demonstrated to be the primary sensor for endogenous bile acids, and play a crucial role in hepatic triglyceride homeostasis. Deciphering the synergistic contributions of FXR to triglyceride metabolism is critical for discovering therapeutic agents in the treatment of NAFLD and hypertriglyceridemia.

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“…Adipocyte differentiation, oil red O staining and lipolysis assay were performed as previously described [19,20]. For Bodipy staining, cells were grown on glass coverslips, fixed in 4% paraformaldehyde and stained with Bodipy 493/503 (Life technology) for 30 min.…”

Section: Isolation and Culture Of Mefs Bscl2mentioning

confidence: 99%

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

Prieur¹,

Dollet²,

Takahashi³

et al. 2013

Diabetologia

136

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Aims/hypothesis Mutations in BSCL2/seipin cause Berardinelli-Seip congenital lipodystrophy (BSCL), a rare recessive disorder characterised by near absence of adipose tissue and severe insulin resistance. We aimed to determine how seipin deficiency alters glucose and lipid homeostasis and whether thiazolidinediones can rescue the phenotype. Methods Bscl2−/− mice were generated and phenotyped. X. Prieur, L. Dollet and M. Takahashi contributed equally to this study.Electronic supplementary material The online version of this article

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The Farnesoid X Receptor Regulates Adipocyte Differentiation and Function by Promoting Peroxisome Proliferator-activated Receptor-γ and Interfering with the Wnt/β-Catenin Pathways

Cited by 85 publications

References 43 publications

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

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