The Family of IL-10-Secreting CD4+ T Cells

Fujio, Keishi; Okamura, Tomohisa; Yamamoto, Kazuhiko

doi:10.1016/s0065-2776(10)05004-2

Cited by 146 publications

(105 citation statements)

References 172 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Because Th2 cytokines were markedly increased in the lung in this study, most CD4 + cells increased in the lung by multiple antigen challenges should be CD4 + Th2 cells; however, it is well known that some dendritic cells and iNKT cells are also CD4 + (38,39 (40,41). We have detected antigen-induced Tr1-type IL-10-producing cells in the lung (T. Nabe et al, unpublished data).…”

Section: Effects Of Anti-il-5 Mab On the Development Of Airway Remodementioning

confidence: 53%

Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice

Nabe¹,

Morishita²,

Matsuya³

et al. 2011

J Pharmacol Sci

View full text Add to dashboard Cite

Abstract. It is known that the late asthmatic response (LAR), a characteristic feature of asthma, is closely associated with CD4 + Th2 cell-mediated allergic inflammation. Airway remodeling is also a pathogenesis of asthma, but literature reporting roles of CD4 + cells in the remodeling is controversial. There has been no study that simultaneously assessed the roles of CD4 + cells in both LAR and airway remodeling. Sensitized mice were intratracheally challenged with ovalbumin 4 times. Treatment with an anti-CD4 monoclonal antibody (mAb) before the 1st challenge almost completely abolished increase in CD4 + cells in the tissues after the 4th challenge. The late phase increase in airway resistance after the 4th challenge was also completely inhibited by anti-CD4 mAb. Parameters of airway remodeling, subepithelial fibrosis and epithelial thickening were attenuated by treatment, whereas the inhibition was only 30% -40%. Bronchial smooth muscle thickening was not affected. Because interleukin (IL)-5 production as well as eosinophilia was effectively suppressed by anti-CD4 mAb, the effect of anti-IL-5 mAb was also examined, resulting in no inhibition of airway remodeling. Collectively, although the LAR was completely dependent on CD4 + cell activation, airway remodeling was only partially dependent on the cell.

show abstract

Section: Effects Of Anti-il-5 Mab On the Development Of Airway Remodementioning

confidence: 53%

Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice

Nabe¹,

Morishita²,

Matsuya³

et al. 2011

J Pharmacol Sci

View full text Add to dashboard Cite

show abstract

“…Tr1 cells secrete high levels of IL-10 and minimal amounts of IL-4 and IL-17, which distinguishes them from Th2 and Th17 cells. 21 Furthermore, depending on the local cytokine milieu, Tr1 cells can produce variable levels of IFN-c. 21 Another feature of Tr1 cells is that they do not express the transcription factor Foxp3. 32 On the contrary, nTreg cells will constitutively express Foxp3 at a level that is closely related to their suppressive ability.…”

Section: Discussionmentioning

confidence: 99%

“…21 Subsequently, we wanted to examine the Foxp3 expression in inducible Treg-ofB1a cells. CD4 1 CD25 2 T (T naive ) cells purified from Foxp3-GFP3DO11.10 transgenic mice were cultured with B-1a or B-2 cells following the previous protocol.…”

Section: B-1a Cells Convert Naive Cd4 1 T Cells Into Foxp3 2 Treg Cellsmentioning

confidence: 99%

A B-1a cell subset induces Foxp3− T cells with regulatory activity through an IL-10-independent pathway

Hsu

Chu

et al. 2014

Cell Mol Immunol

View full text Add to dashboard Cite

“…However, the CD4 + T cell compartment exhibited significant alterations with decreased CD69 expression and increased CTLA-4 expression, indicating an inhibition of T cell activation. In addition, there was an increase in the number of IL-10 + CD4 + T cells in the ppc1-5H MRL-lpr mice, suggesting an induction of the type 1 regulatory T cells (Tr1) (34). Importantly, the ppc1-5 B cells produced more IL-10 than the nontransgenic (tg) B cells upon CpG and LPS stimulation.…”

mentioning

confidence: 95%

Expression of Natural Autoantibodies in MRL-lpr Mice Protects from Lupus Nephritis and Improves Survival

Mannoor

Matejuk

et al. 2012

The Journal of Immunology

View full text Add to dashboard Cite

Natural autoantibodies (NAA) and their associated B cells constitute a substantial proportion of the normal Ab and B cell repertoire. They often have weak reactivity toward a variety of self-Ags such as DNA, nucleoproteins, and phospholipids. It remains controversial whether NAA contribute to or protect from autoimmune diseases. Using site-directed transgenic (sd-tg) mice expressing a prototypic NAA, we investigated the effect of NAA and NAA-producing B cells in disease development in the autoimmune-prone MRL/MpJ-Faslpr (MRL-lpr) mice. We found that the expression of NAA in MRL-lpr mice prevented proteinuria and reduced kidney immune complex formation. The mice had significantly improved survival. Administration of the IgM NAA to MRL-lpr mice also delayed the onset of nephritis. The sd-tg MRL-lpr mice had decreased levels of anti-dsDNA Abs, anti-Hep2 nuclear Abs, and anti-Sm/ribonucleoprotein Abs. There is a shift in the IgG subclass profile from IgG2a and IgG3 to IgG1 in the sd-tg MRL-lpr mice. The CD4+ T cells from the sd-tg MRL-lpr mice had increased expression of the negative costimulatory molecule CTLA-4 and increased production of IL-10 as compared with those from the wild-type mice. Furthermore, the NAA B cells produced large amounts of IL-10 upon TLR stimulation. These results indicate that NAA and NAA-producing B cells play an important role in protection from lupus nephritis and suggest that the NAA B cells may have an immune regulatory function via the provision of IL-10.

show abstract

The Family of IL-10-Secreting CD4+ T Cells

Cited by 146 publications

References 172 publications

Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice

Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice

A B-1a cell subset induces Foxp3− T cells with regulatory activity through an IL-10-independent pathway

Expression of Natural Autoantibodies in MRL-lpr Mice Protects from Lupus Nephritis and Improves Survival

Contact Info

Product

Resources

About