2016
DOI: 10.1111/ejn.13153
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Abstract: The mouse olfactory system employs~1100 G-protein-coupled odorant receptors (ORs). Each mature olfactory sensory neuron (OSN) is thought to express just one OR gene, and the expressed OR determines the odorant response properties of the OSN. The broadest odorant response profile thus far demonstrated in native mouse OSNs is for OSNs that express the OR gene SR1 (also known as Olfr124 and MOR256-3). Here we showed that the odorant responsiveness of native mouse OSNs expressing the OR gene MOR256-17 (also known … Show more

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Cited by 22 publications
(21 citation statements)
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“…Although this possibility cannot be excluded, the in vitro EC 50 values for a neutral and attractive or aversive ligand for the same receptor were in some cases similar, suggesting that there could be other explanations. Because a single TAAR ligand might activate not only multiple TAARs, but also ORs (18,40), one other potential explanation was that, although input from a given TAAR might induce an innate behavior, the behavioral response is not actually resistant to all other receptor inputs. For example, an aversive and neutral ligand for the same TAAR might both activate additional receptors, but one or more of those activated by the neutral ligand blocks the aversive response, whereas those activated by the aversive ligand do not.…”
Section: Numerous Taar Ligands and Other Odorants Induce Innate Respomentioning
confidence: 99%
“…Although this possibility cannot be excluded, the in vitro EC 50 values for a neutral and attractive or aversive ligand for the same receptor were in some cases similar, suggesting that there could be other explanations. Because a single TAAR ligand might activate not only multiple TAARs, but also ORs (18,40), one other potential explanation was that, although input from a given TAAR might induce an innate behavior, the behavioral response is not actually resistant to all other receptor inputs. For example, an aversive and neutral ligand for the same TAAR might both activate additional receptors, but one or more of those activated by the neutral ligand blocks the aversive response, whereas those activated by the aversive ligand do not.…”
Section: Numerous Taar Ligands and Other Odorants Induce Innate Respomentioning
confidence: 99%
“…While an increasing number of mammalian ORs have been screened, few have been screened more than once. When ORs have been characterized in multiple studies, there has been substantial overlap among the odorant screening panels [ 21 , 22 , 26 , 27 ]. Thus, the concern that variation in tuning breadth might be an artifact of our collective screening protocols cannot be easily dismissed.…”
Section: Discussionmentioning
confidence: 99%
“…Unfortunately, the full composition of the screening panel was not provided, so it is difficult to judge how well that panel was distributed across odor space. Recently, the tuning breadth of MOR256-17 was examined in a mouse OSN context and was found to be broad [ 27 ]. The similarity of the set of active compounds identified in this study, to what was identified in the previous screening of MOR256-17 expressed in HEK293 cells [ 33 ] and Xenopus oocytes [ 26 ], supports the use of heterologous systems for OR screening.…”
Section: Discussionmentioning
confidence: 99%
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