The expression patterns and correlations of claudin-6, methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas

Xu, Xiaoming; Jin, Huiying; Liu, Yafang; Liu, Li; Wu, Qiong; Guo, Yanping; Yu, Li; Liu, Zhijing; Zhang, Tingting; Zhang, Xiaowei; Dong, Xiaotian; Quan, Chengshi

doi:10.1186/1746-1596-7-33

Cited by 33 publications

(30 citation statements)

References 41 publications

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“…Little is known about the molecular mechanisms that drive the development and prog ression of malignant tumors within fibroadenomas. Comparative studies that analyzed various molecular markers in fibroadenomas and breast carcinomas failed however to identify the potential drivers [35,36]. However, a clonality study of Kuijper et al [37] indicated that fibroadenomas possessed a potential to progress in an epithelial direction (carcinoma) or in a stromal direction (phyllodes tumor).…”

Section: Discussionmentioning

confidence: 99%

Infarcted fibroadenoma of the breast: report of two new cases with review of the literature

2013

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IntroductionFibroadenomas are the most common benign breast tumors in young women. Infarction is rarely observed in fibroadenomas and when present, it is usually associated with pregnancy or lactation. Infarction can exceptionally occur as a complication of previous fine-needle aspiration biopsy or during lactation and pregnancy.Materials and methodsRetrospective review of 650 cases of fibroadenomas diagnosed at our institution during the 8-years period identified two cases of fibroadenomas with infarction (rate ~0.3%).ResultsTwo partially infarcted fibroadenomas were diagnosed on core biopsy and frozen section in an adolescent girl (13 years old) and in a young woman (25 years old), respectively. No preceding fine-needle aspiration biopsy was performed in these cases, nor were the patients pregnant or lactating at the time of the diagnosis.ConclusionSpontaneous infarction within fibroadenoma is a rare phenomenon in younger patients. The presence of necrosis on core biopsy or frozen section should be cautiously interpreted and is not a sign of malignancy.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1556060549847356

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Section: Discussionmentioning

confidence: 99%

Infarcted fibroadenoma of the breast: report of two new cases with review of the literature

2013

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“…MeCP2 regulates cell proliferation, cell growth and apoptosis in prostate cancer cells (Bernard et al 2006;Yaqinuddin et al 2008). Apart from these reports, MeCP2 has also been linked to cervical cancer (Wang et al 2013) and ductal carcinomas (Xu et al 2012a). Altered MeCP2 expression in gastric cancer has been shown to be mediated by the action of miR-212 (Wada et al 2010).…”

Section: Cancermentioning

confidence: 99%

Rett Syndrome and MeCP2

2014

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Rett syndrome (RTT) is a severe and progressive neurological disorder, which mainly affects young females. Mutations of the methyl-CpG binding protein 2 (MECP2) gene are the most prevalent cause of classical RTT cases. MECP2 mutations or altered expression are also associated with a spectrum of neurodevelopmental disorders such as autism spectrum disorders with recent links to fetal alcohol spectrum disorders. Collectively, MeCP2 relation to these neurodevelopmental disorders highlights the importance of understanding the molecular mechanisms by which MeCP2 impacts brain development, mental conditions, and compromised brain function. Since MECP2 mutations were discovered to be the primary cause of RTT, a significant progress has been made in the MeCP2 research, with respect to the expression, function and regulation of MeCP2 in the brain and its contribution in RTT pathogenesis. To date, there have been intensive efforts in designing effective therapeutic strategies for RTT benefiting from mouse models and cells collected from RTT patients. Despite significant progress in MeCP2 research over the last few decades, there is still a knowledge gap between the in vitro and in vivo research findings and translating these findings into effective therapeutic interventions in human RTT patients. In this review, we will provide a synopsis of Rett syndrome as a severe neurological disorder and will discuss the role of MeCP2 in RTT pathophysiology.

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“…Moreover, claudin-4 has been reported to be highly unregulated in gastric cancer, with an association between the up-regulation of claudin-4 and lymph node metastasis [14]. Claudin-6 protein is significantly down-regulated in breast invasive ductal carcinomas and is an important correlate with lymphatic metastasis [15]. Together such observations suggest that claudin protein expression may be related to the survival and invasion of cancer cells and may have significant clinical relevance.…”

Section: Introductionmentioning

confidence: 99%

The distinct expression patterns of claudin-2, -6, and −11 between human gastric neoplasms and adjacent non-neoplastic tissues

et al. 2013

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BackgroundCancers have a multifactorial etiology a part of which is genetic. Recent data indicate that expression of the tight junction claudin proteins is involved in the etiology and progression of cancer.MethodsTo explore the correlations of the tight junction proteins claudin-2,-6, and −11 in the pathogenesis and clinical behavior of gastric cancer, 40 gastric cancer tissues and 28 samples of non-neoplastic tissues adjacent to the tumors were examined for expression of claudin-2,-6, and −11 by streptavidin-perosidase immunohistochemical staining method.ResultsThe positive expression rates of claudin-2 in gastric cancer tissues and adjacent tissues were 25% and 68% respectively (P < 0.001). The positive expression rates of claudin-6 in gastric cancer tissues and adjacent tissues were 55% and 79% respectively (P = 0.045 < 0.05). In contrast, the positive expression rates of claudin-11 in gastric cancer tissues and gastric cancer adjacent tissues were 80% and 46% (P = 0.004 < 0.01). Thus in our study, the expression of claudin-2, and claudin-6 was down regulated in gastric cancer tissue while the expression of claudin-11 was up regulated. Correlations between claudin expression and clinical behavior were not observed.ConclusionOur study provides the first evidence that claudin-2,-6, and −11 protein expression varies between human gastric cancers and adjacent non-neoplastic tissues.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5470513569630744

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The expression patterns and correlations of claudin-6, methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas

Cited by 33 publications

References 41 publications

Infarcted fibroadenoma of the breast: report of two new cases with review of the literature

Infarcted fibroadenoma of the breast: report of two new cases with review of the literature

Rett Syndrome and MeCP2

The distinct expression patterns of claudin-2, -6, and −11 between human gastric neoplasms and adjacent non-neoplastic tissues

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