2012
DOI: 10.1371/journal.pone.0034688
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Abstract: BackgroundThe microRNAs have been implicated in the process of cardiac development, cardiac hypertrophy, and heart failure. However, the impact of adult aging on cardiac expression of miRNA clusters, as well as both miRNA guide (miR) and passenger (miR*) strands has not been well established.Methods/ResultsWe explored the expression profile of both miR and miR* in the hearts of young adult versus old mice. We found that 65 miRNAs were differentially expressed in the old versus young adult hearts; approximately… Show more

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Cited by 100 publications
(112 citation statements)
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“…Consistent with this, miR-21* has been shown recently to have a pivotal immunopathological function in controlling apoptosis in granulocyte eosinophils in vitro (39). Another study found that miR-21* expression was differentially expressed in the aging mouse heart (40). Of note, extensive deep RNA sequencing in failing human hearts identified miR-21* to be expressed in the human heart and increased during heart failure (41).…”
Section: Methodsmentioning
confidence: 64%
“…Consistent with this, miR-21* has been shown recently to have a pivotal immunopathological function in controlling apoptosis in granulocyte eosinophils in vitro (39). Another study found that miR-21* expression was differentially expressed in the aging mouse heart (40). Of note, extensive deep RNA sequencing in failing human hearts identified miR-21* to be expressed in the human heart and increased during heart failure (41).…”
Section: Methodsmentioning
confidence: 64%
“…Evidence show that miRNAs are differentially expressed in activated ECs, where they suppress proliferation, or permit activation of signals leading to neovascularization 15, 50, 86.…”
Section: Angiogenesis and Mirna‐related Changesmentioning
confidence: 99%
“…Thus, EC dysfunction and ageing‐related degenerative problems lie, at least in part, within the tissue‐specific released miRNAs 6, 15, 29, 50, 51, 80.…”
Section: Circulating Mirnas Associated With Myocardium Functionmentioning
confidence: 99%
“…Malheureusement, ces études restent descriptives et donnent uniquement une indication possible sur la relation entre miARN et vieillissement cardiaque. Zhang et ses collaborateurs ont analysé, chez des rats jeunes et âgés, le profil des miARN et de leur complémentaire miARN *4 , et ont montré des différences pour 61 miARN, notamment une augmentation significative de l'expression de miR-21, un miARN présentant une activité profibrotique [37]. Dans une autre étude, une augmentation de l'expression de miR-22, qui serait à l'origine de l'activation et la sénescence des fibroblastes cardiaques, a été observée [38].…”
Section: Rôle Des Petits Arn Non Codant Miarnunclassified