The Expression and Survival Significance of Glucose Transporter-1 in Pancreatic Cancer: Meta-Analysis, Bioinformatics Analysis and Retrospective Study

Du, Jiali; Gu, Jichun; Deng, Jixin; Kong, Lei; Guo, Yujie; Jin, Chen; Bao, Yun; Fu, Deliang; Li, Ji

doi:10.1080/07357907.2021.1950755

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…The early symptoms of this cancer are very subtle or lacking, so it is often diagnosed after the disease has deteriorated significantly, which makes the early diagnosis rate only 1.43%. With the development of bioinformatics, transcriptomic studies have found that some genes involved in tumorigenesis and metastasis are differentially expressed in tumor and normal tissues [72][73][74][75]. This opens the possibility for early detection of esophageal squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Identification and Validation of Common Reference Genes for Normalization of Esophageal Squamous Cell Carcinoma Gene Expression Profiles

Yang

Shao

et al. 2022

BioMed Research International

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Esophageal squamous cell carcinoma (ESCC) is one of the subtypes of esophageal cancer with Chinese characteristics, and its five-year survival rate is less than 20%. Early diagnosis is beneficial to improving the survival rate of ESCC significantly. Quantitative Real-Time Polymerase Chain Reaction is a high-throughput technique that can quantify tumor-related genes for early diagnosis. Its accuracy largely depends on the stability of the reference gene. There is no systematic scientific basis to demonstrate which reference gene expression is stable in ESCC and no consensus on the selection of internal reference. Therefore, this research used four software programs (The comparative delta-Ct method, GeNorm, NormFinder, and BestKeeper) to evaluate the expression stability of eight candidate reference genes commonly used in other tumor tissues and generated a comprehensive analysis by RefFinder. Randomly selected transcriptome sequencing analysis confirmed the SPP1 gene is closely related to ESCC. It was found that the expression trend of SPP1 obtained by RPS18 and PPIA as internal reference genes were the same as that of sequencing. The results show that RPS18 and PPIA are stable reference genes, and PPIA + RPS18 are a suitable reference gene combination. This is a reference gene report that combines transcriptome sequencing analysis and only focuses on ESCC, which makes the quantification more precise, systematic, and standardized, and promotes gene regulation research and the early diagnosis of ESCC in the future.

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Section: Discussionmentioning

confidence: 99%

Identification and Validation of Common Reference Genes for Normalization of Esophageal Squamous Cell Carcinoma Gene Expression Profiles

Yang

Shao

et al. 2022

BioMed Research International

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“…Glucose transporters (GLUTs) are responsible for transporting glucose across the cell membrane into the cytoplasm. Both GLUT1 and SLC2A1 , which encode GLUT-1 protein, are highly expressed in PC cells and are associated with poor clinical prognosis ( Yu et al, 2017 ; Kurahara et al, 2018 ; Du et al, 2021 ). Activation of KRAS, c-MYC, and HIF-1α in tumors activates GLUT1, which is involved in chemoresistance by promoting the overexpression of GLUT-1 to activate NF-κB and mTOR targets.…”

Section: Alterations In Glucose Metabolismmentioning

confidence: 99%

The role of metabolic reprogramming in pancreatic cancer chemoresistance

Liu

2023

Front. Pharmacol.

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Pancreatic cancer is characterized by hidden onset, high malignancy, and early metastasis. Although a few cases meet the surgical indications, chemotherapy remains the primary treatment, and the resulting chemoresistance has become an urgent clinical problem that needs to be solved. In recent years, the importance of metabolic reprogramming as one of the hallmarks of cancers in tumorigenesis has been validated. Metabolic reprogramming involves glucose, lipid, and amino acid metabolism and interacts with oncogenes to affect the expression of key enzymes and signaling pathways, modifying the tumor microenvironment and contributing to the occurrence of drug tolerance. Meanwhile, the mitochondria are hubs of the three major nutrients and energy metabolisms, which are also involved in the development of drug resistance. In this review, we summarized the characteristic changes in metabolism during the progression of pancreatic cancer and their impact on chemoresistance, outlined the role of the mitochondria, and summarized current studies on metabolic inhibitors.

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“…Moreover, the produced and exported lactate contributes to immunosuppression within the tumor microenvironment ( 53 ). To compensate for the relatively low ATP output compared to mitochondrial oxidative phosphorylation (OXPHOS), the uptake of glucose can be increased by an overexpression of the glucose transporter 1 (GLUT1) ( 54 ). Additionally, phosphorylation on Ser226 in GLUT1 was identified as a key event for the enhanced cell surface localization of GLUT1 and for the regulation of glucose transport ( 55 ).…”

Section: Glucose Lactate and The Metabolic Collaboration In The Tumor...mentioning

confidence: 99%

Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review)

Zuzčák

Trnka

2022

Int J Oncol

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Pancreatic cancer (PC) has one of the highest fatality rates and the currently available therapeutic options are not sufficient to improve its overall poor prognosis. In addition to insufficient effectiveness of anticancer treatments, the lack of clear early symptoms and early metastatic spread maintain the PC survival rates at a low level. Metabolic reprogramming is among the hallmarks of cancer and could be exploited for the diagnosis and treatment of PC. PC is characterized by its heterogeneity and, apart from molecular subtypes, the identification of metabolic subtypes in PC could aid in the development of more individualized therapeutic approaches and may lead to improved clinical outcomes. In addition to the deregulated utilization of glucose in aerobic glycolysis, PC cells can use a wide range of substrates, including branched-chain amino acids, glutamine and lipids to fulfil their energy requirements, as well as biosynthetic needs. The tumor microenvironment in PC supports tumor growth, metastatic spread, treatment resistance and the suppression of the host immune response. Moreover, reciprocal interactions between cancer and stromal cells enhance their metabolic reprogramming. PC stem cells (PCSCs) with an increased resistance and distinct metabolic properties are associated with disease relapses and cancer spread, and represent another significant candidate for therapeutic targeting. The present review discusses the metabolic signatures observed in PC, a disease with a multifaceted and often transient metabolic landscape. In addition, the metabolic pathways utilized by PC cells, as well as stromal cells are discussed, providing examples of how they could present novel targets for therapeutic interventions and elaborating on how interactions between the various cell types affect their metabolism. Furthermore, the importance of PCSCs is discussed, focusing specifically on their metabolic adaptations.

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The Expression and Survival Significance of Glucose Transporter-1 in Pancreatic Cancer: Meta-Analysis, Bioinformatics Analysis and Retrospective Study

Cited by 4 publications

References 35 publications

Identification and Validation of Common Reference Genes for Normalization of Esophageal Squamous Cell Carcinoma Gene Expression Profiles

Identification and Validation of Common Reference Genes for Normalization of Esophageal Squamous Cell Carcinoma Gene Expression Profiles

The role of metabolic reprogramming in pancreatic cancer chemoresistance

Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review)

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