DOI: 10.1002/jcla.24332
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Abstract: Background Although the phosphorylation of 4E‐BP1 that has been detected in high‐grade prostate cancer has been reported in previous studies, overexpression of p4E‐BP1 and 4EBP1 and their clinical significance in prostate cancer still remain unknown. Methods One hundred six samples of prostate tissues were collected and analyzed by immunohistochemistry with p4E‐BP1 or 4E‐BP1 specific antibodies. Everolimus was used to block the phosphorylation of p4E‐BP1, and then flow cytometry, clone formation, transwell, an… Show more

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