The Experimental Production of Cataracts by Exposure to Heat and Light

Impact of iris pigment and pupil size in ultraviolet radiation cataract in rat

“…The reason for this association is not clear, and various theories have been proposed. Heat transfer from iris melanin pigment to the lens might increase ageing processes, as supported by animal experiments with infrared radiation (Langley et al 1960). Free radicals formed from iris melanin by UV radiation (Mason et al 1960) and light exposure (Cope et al 1963) might reach the lens and damage critical molecules.…”

Impact of iris pigment and pupil size in ultraviolet radiation cataract in rat

“…The reason for this association is not clear, and various theories have been proposed. Heat transfer from iris melanin pigment to the lens might increase ageing processes, as supported by animal experiments with infrared radiation (Langley et al 1960). Free radicals formed from iris melanin by UV radiation (Mason et al 1960) and light exposure (Cope et al 1963) might reach the lens and damage critical molecules.…”

Production of Cataracts in Rabbits with the Ultraviolet Laser

“…Although clinically the lenticular changes appear similar to those produced by heat generated at the level of the contacting pigment epithelium of the iris exposed to incoherent white light [10], there is considerable difference in the time of appearance; the cataract produced by the intense UV irradiation develops rather promptly, while that produced by locally generated heat develops more slowly4.…”

ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context

“…In an experimental rabbit model, acute exposure was associated primarily with anterior subcapsular changes (Pitts and Cullen, 1991). Vogt (1932), Goldmann (1933), and Langley et al (1960) described initial changes in the anterior cortical regions of the lens with posterior lens involvement, if at all, only occurring at later stages of opacification. This temporal sequence of lens changes is not found in ionisingradiation-induced cataract.…”

Impact of iris pigment and pupil size in ultraviolet radiation cataract in rat

“…The reason for this association is not clear, and various theories have been proposed. Heat transfer from iris melanin pigment to the lens might increase ageing processes, as supported by animal experiments with infrared radiation (Langley et al 1960). Free radicals formed from iris melanin by UV radiation (Mason et al 1960) and light exposure (Cope et al 1963) might reach the lens and damage critical molecules.…”

Production of Cataracts in Rabbits with the Ultraviolet Laser

“…Although clinically the lenticular changes appear similar to those produced by heat generated at the level of the contacting pigment epithelium of the iris exposed to incoherent white light [10], there is considerable difference in the time of appearance; the cataract produced by the intense UV irradiation develops rather promptly, while that produced by locally generated heat develops more slowly4.…”

ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context

“…In an experimental rabbit model, acute exposure was associated primarily with anterior subcapsular changes (Pitts and Cullen, 1991). Vogt (1932), Goldmann (1933), and Langley et al (1960) described initial changes in the anterior cortical regions of the lens with posterior lens involvement, if at all, only occurring at later stages of opacification. This temporal sequence of lens changes is not found in ionisingradiation-induced cataract.…”

Impact of iris pigment and pupil size in ultraviolet radiation cataract in rat

“…The reason for this association is not clear, and various theories have been proposed. Heat transfer from iris melanin pigment to the lens might increase ageing processes, as supported by animal experiments with infrared radiation (Langley et al 1960). Free radicals formed from iris melanin by UV radiation (Mason et al 1960) and light exposure (Cope et al 1963) might reach the lens and damage critical molecules.…”

Production of Cataracts in Rabbits with the Ultraviolet Laser

“…Although clinically the lenticular changes appear similar to those produced by heat generated at the level of the contacting pigment epithelium of the iris exposed to incoherent white light [10], there is considerable difference in the time of appearance; the cataract produced by the intense UV irradiation develops rather promptly, while that produced by locally generated heat develops more slowly4.…”

ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context

“…In an experimental rabbit model, acute exposure was associated primarily with anterior subcapsular changes (Pitts and Cullen, 1991). Vogt (1932), Goldmann (1933), and Langley et al (1960) described initial changes in the anterior cortical regions of the lens with posterior lens involvement, if at all, only occurring at later stages of opacification. This temporal sequence of lens changes is not found in ionisingradiation-induced cataract.…”