The expanding clinical spectrum of multisystem disease associated with eosinophilia

Kaufman, L. D.

doi:10.1001/archderm.133.2.225

Cited by 8 publications

(8 citation statements)

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“…32 Eosinophil activation in diseases associated with fibrosis and necrosis can modulate fibroblasts activity through the release of biologically active compounds that exhibit either fibrogenic or fibrolytic activities. [32][33][34] In addition to its granule content of cationic proteins such as ECP, major basic protein, and eosinophil peroxidase with known toxic effects on various cells and tissues including bladder epithelium, 35,36 eosinophils are now known to have the capacity to express, store, and release an array of up to 18 different cytokines, chemokines, and growth factors, including interleukin-3 (IL-3), IL-4, IL-5, IL-6, regulated upon activation normal T lymphocyte expressed and secreted (RAN-TES), granulocyte-macrophage-colony stimulating factor, tumor necrosis factor-␣, and transforming growth factor-␤. 37 Moreover, eosinophils have been shown to express major histocompatibility class II and CD4 molecules and act as antigen presenting cells in vitro.…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity.

Reimert¹,

Mshinda²,

Hatz³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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Abstract. Eosinophiluria, as quantified by measuring eosinophil cationic protein (ECP) in urinary extracts, microhematuria, egg excretion, and ultrasound-detectable bladder pathology were recorded in Schistosoma haematobium-infected Tanzanian school children at a baseline survey and during an 18-month post-treatment followup study. Significant correlations were seen between urinary ECP levels, intensity of infection, and bladder pathology. Treatment resulted in a marked reduction in prevalence and intensity of infection, in a delayed and less marked reduction in ECP levels, and in a resolution of pathology. The overall diagnostic efficiency of the ECP test (cut-off value for the ECP Ն5 ng/ml) in relation to infection was comparable with that of egg count and microhematuria, but with a better sensitivity than a single egg count. In relation to bladder pathology, the diagnostic performance of the ECP test (cut-off value for the ECP Ն25 ng/ml) exceeded that of a single egg count. In addition, the ECP was better in discriminating between different grades of bladder pathology. The present study points to the ECP as a useful marker of both S. haematobium infection and of associated bladder morbidity reflecting the inflammatory status of the bladder wall.

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Section: Discussionmentioning

confidence: 99%

Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity.

Reimert¹,

Mshinda²,

Hatz³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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“…NSAIDS). Eosinophilia-Myalgia Syndrome and Toxic Oil Syndrome - The eosinophilia-myalgia syndrome (EMS) [69] and toxic oil syndrome are both chronic, persisting multisystem diseases in which marked eosinophilia is present [70]. The toxic oil syndrome was due to ingestion of cooking oil adulterated with denatured rapeseed oil [71] and an outbreak of EMS was associated with ingestion of contaminated L-tryptophan.…”

Section: Hypereosinophilia With Organ-restricted Involvementmentioning

confidence: 99%

Evaluation and Differential Diagnosis of Marked, Persistent Eosinophilia

Mejia

Nutman

2012

Seminars in Hematology

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“…Other authors have reported overlapping clinical and histopathological findings in Wells' syndrome (WS) and the hyper‐eosinophilic syndrome 3 . Kaufman 4 recently reviewed this issue, concluding that although the diseases of this group might present as systemic manifestations or skin disorders alone (e.g. WS), all the forms are accompanied by a similar mechanism of activation of eosinophils via various lymphokines.…”

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Wells' syndrome (eosinophilic cellulitis): correlation between clinical activity, eosinophil levels, eosinophil cation protein and interleukin-5

España¹,

Ml²,

Sola

et al. 1999

British Journal of Dermatology

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Wells' syndrome (WS) (eosinophilic cellulitis) is characterized by the presence of oedematous skin lesions associated with eosinophilia of the tissues. It has recently been observed that in patients with this disease, increased eosinophil cation protein (ECP) and interleukin (IL) -5 can be detected in peripheral blood, with T lymphocytes that have mRNA for this lymphokine. We present a patient with WS in whom we found a close correlation between clinical activity, eosinophils in blood and bone marrow, and ECP and IL-5 levels in peripheral blood and tissues. We underline the major part played by IL-5 in this disease.

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The expanding clinical spectrum of multisystem disease associated with eosinophilia

Cited by 8 publications

References 0 publications

Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity.

Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity.

Evaluation and Differential Diagnosis of Marked, Persistent Eosinophilia

Wells' syndrome (eosinophilic cellulitis): correlation between clinical activity, eosinophil levels, eosinophil cation protein and interleukin-5

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