2019
DOI: 10.1111/acel.12916
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Abstract: Naked mole‐rats (NMRs) are mouse‐sized mammals that exhibit an exceptionally long lifespan (>30 vs. <4 years for mice), and resist aging‐related pathologies such as cardiovascular and pulmonary diseases, cancer, and neurodegeneration. However, the mechanisms underlying this exceptional longevity and disease resistance remain poorly understood. The oxidative stress theory of aging posits that (a) senescence results from the accumulation of oxidative damage inflicted by reactive oxygen species (ROS) of mitochond… Show more

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Cited by 59 publications
(66 citation statements)
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References 50 publications
(113 reference statements)
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“…This raises the concern that past studies might have underestimated superoxide/H 2 O 2 formation rates of short‐lived species. In our case, rates of superoxide/H 2 O 2 formation were always lower for mice when a five minutes of equilibration period was observed before addition of succinate ( n = 3), whereas acquiring data immediately after addition of mitochondria to the chambers resulted in significantly higher rates for mice as compared to NMR (Munro et al, ).…”
Section: Other Bias In Measuring Ros Production In the Context Of Commentioning
confidence: 54%
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“…This raises the concern that past studies might have underestimated superoxide/H 2 O 2 formation rates of short‐lived species. In our case, rates of superoxide/H 2 O 2 formation were always lower for mice when a five minutes of equilibration period was observed before addition of succinate ( n = 3), whereas acquiring data immediately after addition of mitochondria to the chambers resulted in significantly higher rates for mice as compared to NMR (Munro et al, ).…”
Section: Other Bias In Measuring Ros Production In the Context Of Commentioning
confidence: 54%
“…This effect seems to primarily involve superoxide production at site I Q as it is observed in the presence of succinate as the sole respiratory substrate, but absent when rotenone is added (Treberg, Braun, Zacharias, & Kroeker, ). Preliminary tests for our recent study (Munro, Baldy, Pamenter, & Treberg, ) showed that the time spent (in the absence of substrates) by mice skeletal muscle mitochondria inside the chambers of the Oroboros, before addition of substrates, also leads to a pronounced decline in the capacity for superoxide/H 2 O 2 generation at site I Q (succinate alone, Figure ). This effect is however not seen in the presence of glutamate + malate and is also not observed in mitochondria of the long‐lived naked mole‐rat (NMR, not shown in Figure ).…”
Section: Other Bias In Measuring Ros Production In the Context Of Commentioning
confidence: 88%
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