The Evolving Roles of <i>Bacopa monnieri</i> as Potential Anti-Cancer Agent: A Review

Ghosh, Sudeepa; Khanam, Rahmat; Chowdhury, Avik Acharya

doi:10.1080/01635581.2020.1841248

Cited by 22 publications

(7 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bacoside A is the well studied potential triterpenoid saponin of B. monnieri, which is composed of bacoside A3, bacopasaponin C, bacopaside II and a jujubogenin isomer of bacosaponin C. 8 To date, bacosides and triterpenoid saponins have been able to repair neuronal damage, promote kinase enzyme activity, restore synaptic activity, and enhance the neural impulse transmission. Bacopa acts pharmacologically as antifungal, 9 antidepressant, 5,10 antiepileptic, 11,12 antioxidant, 11,13 anti-inflammatory, 14,15 antitoxic, 16 antibacterial, 9 anticancer, 17 memory enhancer, 18 analgesic, 19 hepatoprotective, 20 antihyperglycemic, 21 and anticonvulsant. 22 The anti-inflammatory effect of Bacopa may also be related to neuroprotective effects.…”

Section: ■ Introductionmentioning

confidence: 99%

“…To date, bacosides and triterpenoid saponins have been able to repair neuronal damage, promote kinase enzyme activity, restore synaptic activity, and enhance the neural impulse transmission. Bacopa acts pharmacologically as antifungal, antidepressant, , antiepileptic, , antioxidant, , anti-inflammatory, , antitoxic, antibacterial, anticancer, memory enhancer, analgesic, hepatoprotective, antihyperglycemic, and anticonvulsant …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessing the Anti-inflammatory Effects of Bacopa-Derived Bioactive Compounds Using Network Pharmacology andIn VitroStudies

et al. 2022

View full text Add to dashboard Cite

Bacopa monnieri is reported as a potent Indian medicinal plant that possesses numerous pharmacological activities due to the presence of various bioactive compounds. These pharmacological activities were used in the ancient medicine system to cure inflammatory conditions. Bacopa has the ability to reduce acute pain and inflammation by inhibiting the enzyme cyclo-oxygenase-2 (COX-2) and reducing COX-2-arbitrated prostanoid mediators. Moreover, the anti-inflammatory property may also be associated with the neuroprotective activity of Bacopa. Considering this importance, the current pilot study focused on the anti-inflammatory potential of various phytocompounds of bacopa and their interaction with inflammation responsible genes such as COX2, iNOS, LOX, STAT3, CCR1, and MMP9 through pharmacology analysis of its systems. Docking results revealed that, quercetin (QR) showed significant binding energies with inflammatory genes. Hence, we selected QR as a potential phytocompound for further in vitro experiments. This existing study aimed to evaluate the efficacy of QR as a potent anti-inflammatory compound against lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The in vitro analysis concludes that QR effectively reduces the production of nitric oxide (NO) in LPS-induced RAW264.7 cells and downregulates the expression of COX-2 and iNOS genes due to the inhibitory potential of QR on LPS-stimulated NO production.

show abstract

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessing the Anti-inflammatory Effects of Bacopa-Derived Bioactive Compounds Using Network Pharmacology andIn VitroStudies

et al. 2022

View full text Add to dashboard Cite

show abstract

“…[293] Practically major phytoconstituent found in Bacopa monnieri has been demonstrated in cancer cells to exhibit anti-metastatic, anti-angiogenic, and anti-proliferative effects. [294]…”

Section: Antidiabetic Prospectivementioning

confidence: 99%

In Quest of the Mysterious Holistic Vedic Herb Bacopa monnieri (L.) Pennell

Mondal¹,

Bhar²,

Mondal³

et al. 2023

Pharmacogn. Res.

View full text Add to dashboard Cite

Throughout history, complementary and alternative therapies have been widely utilised. In recent years, there has been a surge in interest in the usage of herbal treatments all around the world. Various natural chemicals, such as those produced from plants, have been investigated as potential therapies for a myriad of ailments. The essence of this review was to methodically describe everything we know about Bacopa monnieri (L.) Pennell, a mysterious holistic Vedic herb belonging to the Plantaginaceae family, a well-known nootropic and effective memory enhancer, which has recently emerged as one of the most important medical herbs, widely used therapeutically in the Orient and growing in popularity around the world. Literature was gathered from sources such as Scopus, PubMed, Google Scholar, and ScienceDirect, and reviewed using the Prisma quality metacritic paradigm. It is now plainly obvious that current therapies fall short of meeting the demands of the vast majority of individuals with health problems, and traditional medicines are gaining appeal as a result of their reduced toxicity. Bacopa is a traditional herb used in Ayurvedic medicine to treat brain and nerve weariness, as well as in Siddha medicine to treat impaired memory. It's also used to cure brain and nerve exhaustion in Unani medicine. We improved Brahmi micropropagation and secondary metabolite biosynthesis by compiling pharmacobotanical and pharmacognostical descriptions, as well as ethnoarchaeological data and nanotechnology domination. This critique also highlights our contemporary information of pharmacological activity, preclinical and clinical investigations, significant bioactives, reported mechanisms of action, clinical effectiveness, safety, and the potential for herb-drug interactions. At the same time, the current incarnation of research at the plant is reviewed, as well as future research possibilities. Brahmi offers a lot of potential for treating a range of illnesses, including neuro-pharmacological, depression, inflammation, hepatoprotective, antidiabetic, and others. According to the presumptions of this review, further clinical trials and research are needed. While the impact of Brahmi as an anxiolytic and antidepressant has to be explored further, its potential as an anti-epileptic therapy and a treatment for antiepileptic drugs side effects is also being researched. Furthermore, Brahmi's antioxidant ability may explain, at least in part, the antistress, immunomodulatory, cognition-facilitating, anti-inflammatory, and anti-aging benefits documented in experimental animals and clinical circumstances, necessitating further study into its other therapeutic characteristics.

show abstract

“…In vitro testing on human lymphocytes has found that extracts from B. monnieri are successful in exhibiting antimutagenic and free radical scavenging abilities with no evidence of genotoxic activity [12]. These active constituents have been shown to have anticancer activity in addition to cytotoxic, antimutagenic, and anti-inflammatory properties [13].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Bioavailability and Efficacy of Bacopa Extract and Ebelin Lactone: Preparation and Biological Evaluation

KN,

Aluri,

Shetty

et al. 2024

AJOB

View full text Add to dashboard Cite

Although Bacopa monnieri extract is well known for its cognitive and memory support, it has received minimal attention in pharmacy due to its terrible palatability and poor bioavailability. This study aimed to develop an improved, cost-effective, and eco-friendly process for the preparation of stable and highly bioavailable non-hygroscopic bacosides enriched fraction in such a manner that it contains a specific amount of Bacoside A3 and jujubogenin, and the aglycone derivative (Ebelin lactone). We prepared two compositions 1 and 2 having Bacoside A3 and jujubogenin: Ebelin lactone ratios 1:1 and 3:1 respectively. The efficacy of these herbal compositions was evaluated independently in comparison to the bioactivity of bacosides (20%), bacosides (50%), and Ebelin lactone. This study also aimed to find a wide range of potential activities of formulated composition, including acetylcholinesterase (AChE) inhibitor activity, anti-oxidant activity, cyclooxygenase (COX) inhibitor activity, and anti-cancer activity. We noted that both compositions worked better than parent Bacopa for biological activity assays but the herbal Bacopa Composition 1 is more potent than Composition 2. Hence, further research on Composition 1 should be explored for its potential to treat conditions such as Alzheimer's and various cancer diseases.

show abstract

The Evolving Roles of Bacopa monnieri as Potential Anti-Cancer Agent: A Review

Cited by 22 publications

References 91 publications

Assessing the Anti-inflammatory Effects of Bacopa-Derived Bioactive Compounds Using Network Pharmacology andIn VitroStudies

Assessing the Anti-inflammatory Effects of Bacopa-Derived Bioactive Compounds Using Network Pharmacology andIn VitroStudies

In Quest of the Mysterious Holistic Vedic Herb Bacopa monnieri (L.) Pennell

Enhanced Bioavailability and Efficacy of Bacopa Extract and Ebelin Lactone: Preparation and Biological Evaluation

Contact Info

Product

Resources

About