volume 18, issue 2, P369-394 2004
DOI: 10.1016/j.idc.2004.01.010
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Cristian Apetrei, Preston A. Marx, Stephen M. Smith

Abstract: Since the beginning of the AIDS epidemic in 1981, HIV-1 has demonstrated an amazing ability to mutate. HIV-1 was introduced into the human population in the early to mid twentieth century in central Africa. During ensuing decades, this extraordinary mutational capacity has resulted in the circulation of HIV-1 strains that are quite different from one another, yet still remarkably pathogenic. The potential impact of this viral diversity on treatment, monitoring,and vaccine development is discussed.